Info
| ID | 2200 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 4, "P": 1} |
| Abbreviation | 4 |
| SMILES | C1N2CN3CN1CP(C2)C3.C1N2CN3CN1CP(C2)C3.[Cl-].[Cl-].c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C24H32N8P2Ru/(1-37)(2-41)(3-33)(4-42)(5-51)(6-51)(7-52)(8-52)(9-45)(10-45)(11-34)(12-36)(13-46)(14-46)(15-47)(16-47)(17-53)(18-53)(19-48)(20-54)(21-35)(22-54)(23-55)(24-48)(25-49)(26-49)(27-55)(28-50)(29-50)(30-56)(31-38)(32-56)(33-34)(33-39)(34-41)(35-36)(35-40)(36-42)(37-38)(37-39)(38-40)(39-43)(40-44)(41-63)(42-64)(43-44)(43-63)(44-64)(45-57)(45-58)(46-57)(46-59)(47-58)(47-59)(48-60)(48-61)(49-60)(49-62)(50-61)(50-62)(51-57)(51-65)(52-58)(52-65)(53-59)(53-65)(54-60)(54-66)(55-61)(55-66)(56-62)(56-66)(63-67)(64-67)(65-67)(66-67)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| RPMI-8226 | 66 | — | 10.1039/c7dt02051a | 2017 |
| U266 | 98 | — | 10.1039/c7dt02051a | 2017 |
🧬 Cell Death Types (1)
Necroptosis
medium
«The results show that an increase in PI+/Ann-V− (necrotic cells) was observed in compound 4-treated cells, while low or no effect was evidenced with the other Ru complexes in both cell lines (Fig. 2S ...»