Info
| ID | 2199 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4, "P": 1} |
| Abbreviation | 2 |
| SMILES | C1N2CN3CN1CP(C2)C3.C1N2CN3CN1CP(C2)C3.C1N2CN3CN1CP(C2)C3.[Cl-].c1ccc(-c2ccccn2)nc1 |
TUCAN
C28H44N11P3Ru/(1-64)(2-45)(3-64)(4-48)(5-65)(6-46)(7-51)(8-65)(9-66)(10-66)(11-67)(12-67)(13-68)(14-68)(15-69)(16-55)(17-55)(18-56)(19-52)(20-69)(21-70)(22-70)(23-71)(24-56)(25-57)(26-57)(27-58)(28-58)(29-59)(30-59)(31-60)(32-60)(33-61)(34-61)(35-71)(36-50)(37-72)(38-72)(39-62)(40-62)(41-63)(42-63)(43-47)(44-49)(45-46)(45-53)(46-48)(47-49)(47-54)(48-51)(49-50)(50-52)(51-82)(52-83)(53-54)(53-82)(54-83)(55-73)(55-74)(56-73)(56-75)(57-74)(57-75)(58-76)(58-78)(59-76)(59-77)(60-77)(60-78)(61-79)(61-81)(62-79)(62-80)(63-80)(63-81)(64-73)(64-84)(65-75)(65-84)(66-74)(66-84)(67-76)(67-85)(68-77)(68-85)(69-78)(69-85)(70-79)(70-86)(71-80)(71-86)(72-81)(72-86)(82-87)(83-87)(84-87)(85-87)(86-87)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| RPMI-8226 | 1.4e+02 | — | 10.1039/c7dt02051a | 2017 |
| U266 | 1.9e+02 | — | 10.1039/c7dt02051a | 2017 |
🧬 Cell Death Types (1)
Necroptosis
medium
«The results show that an increase in PI+/Ann-V− (necrotic cells) was observed in compound 4-treated cells, while low or no effect was evidenced with the other Ru complexes in both cell lines (Fig. 2S ...»