Info
| ID | 2198 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 4, "P": 1} |
| Abbreviation | 1 |
| SMILES | C1N2CN3CN1CP(C2)C3.C1N2CN3CN1CP(C2)C3.[Cl-].[Cl-].c1ccc(-c2ccccn2)nc1 |
TUCAN
C22H32N8P2Ru/(1-33)(2-34)(3-37)(4-39)(5-49)(6-49)(7-50)(8-50)(9-43)(10-43)(11-35)(12-51)(13-51)(14-40)(15-44)(16-44)(17-45)(18-45)(19-52)(20-52)(21-46)(22-46)(23-47)(24-53)(25-53)(26-47)(27-48)(28-48)(29-54)(30-38)(31-36)(32-54)(33-34)(33-41)(34-35)(35-39)(36-38)(36-40)(37-38)(37-42)(39-61)(40-62)(41-42)(41-61)(42-62)(43-55)(43-56)(44-55)(44-57)(45-56)(45-57)(46-58)(46-60)(47-58)(47-59)(48-59)(48-60)(49-55)(49-63)(50-56)(50-63)(51-57)(51-63)(52-58)(52-64)(53-59)(53-64)(54-60)(54-64)(61-65)(62-65)(63-65)(64-65)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| RPMI-8226 | 1.6e+02 | — | 10.1039/c7dt02051a | 2017 |
| U266 | 2e+02 | — | 10.1039/c7dt02051a | 2017 |
🧬 Cell Death Types (1)
Necroptosis
medium
«The results show that an increase in PI+/Ann-V− (necrotic cells) was observed in compound 4-treated cells, while low or no effect was evidenced with the other Ru complexes in both cell lines (Fig. 2S ...»