home← all complexes D-MPNN

Complex #2196 — Ru(2) [1]

2D Structure

Structure
⬇ MOL V3000

Info

ID2196
MetalRu
Oxidation state2
Charge1
Donor atoms{"N": 4, "O": 1, "P": 2}
Abbreviation1
SMILESCc1c[nH]c(=O)nc1[O-].c1ccc(-c2ccccn2)nc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1

TUCAN

C51H43N4O2P2Ru/(1-46)(2-49)(3-50)(4-54)(5-45)(6-51)(7-47)(8-52)(9-48)(10-53)(11-55)(12-44)(13-71)(14-44)(15-60)(16-57)(17-58)(18-61)(19-56)(20-64)(21-59)(22-62)(23-70)(24-63)(25-83)(26-69)(27-65)(28-66)(29-72)(30-73)(31-74)(32-76)(33-77)(34-75)(35-84)(36-67)(37-68)(38-78)(39-82)(40-44)(41-80)(42-79)(43-95)(44-81)(45-46)(45-49)(46-89)(47-49)(47-50)(48-51)(48-54)(50-89)(51-90)(52-55)(52-90)(53-57)(53-91)(54-55)(56-58)(56-91)(57-60)(58-60)(59-61)(59-64)(61-62)(62-65)(63-66)(63-70)(64-92)(65-92)(66-93)(67-68)(67-71)(68-85)(69-70)(69-72)(71-83)(72-93)(73-74)(73-94)(74-77)(75-76)(75-94)(76-77)(78-80)(78-86)(79-80)(79-84)(81-82)(81-87)(82-95)(83-96)(84-97)(85-86)(85-96)(86-97)(87-98)(87-99)(88-95)(88-98)(88-100)(89-101)(90-101)(91-101)(92-102)(93-102)(94-102)(96-103)(97-103)(98-103)(101-103)(102-103)

Measurements (40)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
B16-F100.01— 10.1039/c7nj04368f 2018
HL600.01— 10.1039/c7nj04368f 2018
K-5620.1— 10.1039/c7nj04368f 2018
SCC-40.21— 10.1016/j.biopha.2025.118080 2025
HepG20.82— 10.1016/j.biopha.2025.118080 2025
SCC-90.88— 10.1016/j.biopha.2025.118080 2025
HSC-31.1— 10.3390/ijms19061609 2018
CAL-271.1— 10.1016/j.biopha.2025.118080 2025
PBMC1.2— 10.1039/c7nj04368f 2018
BJ1.3— 10.1016/j.biopha.2025.118080 2025
K-5621.3— 10.3390/ijms19061609 2018
HL601.4— 10.3390/ijms19061609 2018
B16-F101.4— 10.3390/ijms19061609 2018
Jurkat1.5— 10.1016/j.biopha.2025.118080 2025
HL601.5— 10.1016/j.biopha.2025.118080 2025
K-5621.5— 10.1016/j.biopha.2025.118080 2025
PANC-11.5— 10.1016/j.biopha.2025.118080 2025
HCT-1161.6— 10.3390/ijms19061609 2018
A3751.7— 10.1016/j.biopha.2025.118080 2025
PBMC1.7— 10.3390/ijms19061609 2018
SCC-251.7— 10.1016/j.biopha.2025.118080 2025
NB41.8— 10.1016/j.biopha.2025.118080 2025
HepG21.8— 10.1039/c7nj04368f 2018
HSC-32— 10.1016/j.biopha.2025.118080 2025
B16-F102.1— 10.1016/j.biopha.2025.118080 2025
OVCAR-32.1— 10.1016/j.biopha.2025.118080 2025
THP-12.4— 10.1016/j.biopha.2025.118080 2025
SCC-92.4— 10.3390/ijms19061609 2018
KG-1a2.4— 10.1016/j.biopha.2025.118080 2025
MDA-MB-2312.5— 10.1016/j.biopha.2025.118080 2025
DU-1452.6— 10.1016/j.biopha.2025.118080 2025
U-87 MG2.6— 10.1016/j.biopha.2025.118080 2025
MCF-72.7— 10.1016/j.biopha.2025.118080 2025
HepG22.8— 10.3390/ijms19061609 2018
A5493.1— 10.1016/j.biopha.2025.118080 2025
4T13.2— 10.1016/j.biopha.2025.118080 2025
MRC-53.8— 10.1016/j.biopha.2025.118080 2025
PBMC5.3— 10.1016/j.biopha.2025.118080 2025
MCF-711— 10.3390/ijms19061609 2018
MRC-512— 10.3390/ijms19061609 2018

🧬 Cell Death Types (1)

Apoptosis high
«the [Ru(PPh3)2(Thy)(bipy)]PF6 complex displays potent cytotoxicity to different cancer cells and induces caspase-mediated apoptosis in HL-60 cells»