home← all complexes Ir builderC^N familiesD-MPNN

Complex #2196 — Ru(2) [1]

2D Structure

Structure
⬇ MOL V3000

Info

ID2196
MetalRu
Oxidation state2
Charge1
Donor atoms{"N": 4, "O": 1, "P": 2}
Abbreviation1
SMILESCc1c[nH]c(=O)nc1[O-].c1ccc(-c2ccccn2)nc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1

TUCAN

C51H43N4O2P2Ru/(1-46)(2-49)(3-50)(4-54)(5-45)(6-51)(7-47)(8-52)(9-48)(10-53)(11-55)(12-44)(13-71)(14-44)(15-60)(16-57)(17-58)(18-61)(19-56)(20-64)(21-59)(22-62)(23-70)(24-63)(25-83)(26-69)(27-65)(28-66)(29-72)(30-73)(31-74)(32-76)(33-77)(34-75)(35-84)(36-67)(37-68)(38-78)(39-82)(40-44)(41-80)(42-79)(43-95)(44-81)(45-46)(45-49)(46-89)(47-49)(47-50)(48-51)(48-54)(50-89)(51-90)(52-55)(52-90)(53-57)(53-91)(54-55)(56-58)(56-91)(57-60)(58-60)(59-61)(59-64)(61-62)(62-65)(63-66)(63-70)(64-92)(65-92)(66-93)(67-68)(67-71)(68-85)(69-70)(69-72)(71-83)(72-93)(73-74)(73-94)(74-77)(75-76)(75-94)(76-77)(78-80)(78-86)(79-80)(79-84)(81-82)(81-87)(82-95)(83-96)(84-97)(85-86)(85-96)(86-97)(87-98)(87-99)(88-95)(88-98)(88-100)(89-101)(90-101)(91-101)(92-102)(93-102)(94-102)(96-103)(97-103)(98-103)(101-103)(102-103)

Measurements (40)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
B16-F100.01— 10.1039/c7nj04368f 2018
HL600.01— 10.1039/c7nj04368f 2018
K-5620.1— 10.1039/c7nj04368f 2018
SCC-40.21— 10.1016/j.biopha.2025.118080 2025
HepG20.82— 10.1016/j.biopha.2025.118080 2025
SCC-90.88— 10.1016/j.biopha.2025.118080 2025
HSC-31.1— 10.3390/ijms19061609 2018
CAL-271.1— 10.1016/j.biopha.2025.118080 2025
PBMC1.2— 10.1039/c7nj04368f 2018
BJ1.3— 10.1016/j.biopha.2025.118080 2025
K-5621.3— 10.3390/ijms19061609 2018
HL601.4— 10.3390/ijms19061609 2018
B16-F101.4— 10.3390/ijms19061609 2018
Jurkat1.5— 10.1016/j.biopha.2025.118080 2025
HL601.5— 10.1016/j.biopha.2025.118080 2025
K-5621.5— 10.1016/j.biopha.2025.118080 2025
PANC-11.5— 10.1016/j.biopha.2025.118080 2025
HCT-1161.6— 10.3390/ijms19061609 2018
A3751.7— 10.1016/j.biopha.2025.118080 2025
PBMC1.7— 10.3390/ijms19061609 2018
SCC-251.7— 10.1016/j.biopha.2025.118080 2025
NB41.8— 10.1016/j.biopha.2025.118080 2025
HepG21.8— 10.1039/c7nj04368f 2018
HSC-32— 10.1016/j.biopha.2025.118080 2025
B16-F102.1— 10.1016/j.biopha.2025.118080 2025
OVCAR-32.1— 10.1016/j.biopha.2025.118080 2025
THP-12.4— 10.1016/j.biopha.2025.118080 2025
SCC-92.4— 10.3390/ijms19061609 2018
KG-1a2.4— 10.1016/j.biopha.2025.118080 2025
MDA-MB-2312.5— 10.1016/j.biopha.2025.118080 2025
DU-1452.6— 10.1016/j.biopha.2025.118080 2025
U-87 MG2.6— 10.1016/j.biopha.2025.118080 2025
MCF-72.7— 10.1016/j.biopha.2025.118080 2025
HepG22.8— 10.3390/ijms19061609 2018
A5493.1— 10.1016/j.biopha.2025.118080 2025
4T13.2— 10.1016/j.biopha.2025.118080 2025
MRC-53.8— 10.1016/j.biopha.2025.118080 2025
PBMC5.3— 10.1016/j.biopha.2025.118080 2025
MCF-711— 10.3390/ijms19061609 2018
MRC-512— 10.3390/ijms19061609 2018

🧬 Cell Death Types (1)

Apoptosis high
«the [Ru(PPh3)2(Thy)(bipy)]PF6 complex displays potent cytotoxicity to different cancer cells and induces caspase-mediated apoptosis in HL-60 cells»

Source-assisted 2D generator

Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.

experimental validation surface
Loading source metadata…
The generated SVG will appear here. The legacy ligand image above stays visible for side-by-side review.