Info
| ID | 2178 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 4, "S": 2, "P": 2} |
| Abbreviation | 4 |
| SMILES | Cc1cc(=O)[nH]c([S-])n1.Cc1cc(=O)[nH]c([S-])n1.c1ccc(P(CCCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C38H38N4O2P2RuS2/(1-63)(2-69)(3-42)(4-43)(5-47)(6-50)(7-41)(8-63)(9-64)(10-54)(11-48)(12-45)(13-46)(14-51)(15-69)(16-52)(17-53)(18-56)(19-64)(20-70)(21-70)(22-55)(23-49)(24-57)(25-58)(26-60)(27-61)(28-59)(29-39)(30-39)(31-44)(32-39)(33-40)(34-40)(35-40)(36-62)(37-77)(38-78)(39-65)(40-66)(41-43)(41-71)(42-43)(42-47)(44-65)(44-67)(45-47)(45-71)(46-50)(46-72)(48-50)(48-54)(49-55)(49-57)(51-54)(51-72)(52-55)(52-73)(53-57)(53-73)(56-58)(56-74)(58-61)(59-60)(59-74)(60-61)(62-66)(62-68)(63-64)(63-69)(64-70)(65-79)(66-80)(67-77)(67-81)(68-78)(68-82)(69-83)(70-84)(71-83)(72-83)(73-84)(74-84)(75-77)(75-79)(75-85)(76-78)(76-80)(76-86)(79-87)(80-87)(83-87)(84-87)
Measurements (14)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HL60 | 0.13 | — | 10.1038/s41598-019-47914-x | 2019 |
| HL60 | 0.15 | — | 10.1016/j.jinorgbio.2019.11075... | 2019 |
| K-562 | 0.32 | — | 10.1016/j.jinorgbio.2019.11075... | 2019 |
| K-562 | 0.34 | — | 10.1038/s41598-019-47914-x | 2019 |
| HepG2 | 0.81 | — | 10.1016/j.jinorgbio.2019.11075... | 2019 |
| HepG2 | 0.83 | — | 10.1038/s41598-019-47914-x | 2019 |
| B16-F10 | 1 | — | 10.1038/s41598-019-47914-x | 2019 |
| HCT-116 | 1.2 | — | 10.1038/s41598-019-47914-x | 2019 |
| SCC-4 | 1.2 | — | 10.1038/s41598-019-47914-x | 2019 |
| PBMC | 1.2 | — | 10.1038/s41598-019-47914-x | 2019 |
| PBMC | 1.3 | — | 10.1016/j.jinorgbio.2019.11075... | 2019 |
| B16-F10 | 1.3 | — | 10.1016/j.jinorgbio.2019.11075... | 2019 |
| HSC-3 | 2 | — | 10.1038/s41598-019-47914-x | 2019 |
| MRC-5 | 3.1 | — | 10.1038/s41598-019-47914-x | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«cotreatment with a pan-caspase inhibitor (Z-VAD(OMe)-FMK) reduced the apoptosis caused by both complexes, indicating a caspase-mediated apoptotic cell death.»