Info
| ID | 2176 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 4, "S": 2, "P": 2} |
| Abbreviation | 2 |
| SMILES | Cc1cc(=O)[nH]c([S-])n1.Cc1cc(=O)[nH]c([S-])n1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C46H40N4O2P2RuS2/(1-43)(2-48)(3-44)(4-45)(5-51)(6-46)(7-41)(8-47)(9-52)(10-53)(11-50)(12-55)(13-56)(14-41)(15-61)(16-57)(17-60)(18-62)(19-54)(20-69)(21-58)(22-70)(23-64)(24-66)(25-59)(26-41)(27-42)(28-42)(29-42)(30-63)(31-65)(32-68)(33-67)(34-73)(35-71)(36-72)(37-49)(38-74)(39-87)(40-88)(41-75)(42-76)(43-46)(43-48)(44-47)(44-48)(45-50)(45-53)(46-79)(47-79)(49-75)(49-77)(50-80)(51-53)(51-55)(52-56)(52-61)(54-57)(54-61)(55-80)(56-81)(57-81)(58-60)(58-69)(59-62)(59-69)(60-82)(62-82)(63-64)(63-70)(64-83)(65-66)(65-70)(66-83)(67-68)(67-84)(68-72)(71-72)(71-73)(73-84)(74-76)(74-78)(75-89)(76-90)(77-87)(77-91)(78-88)(78-92)(79-93)(80-93)(81-93)(82-94)(83-94)(84-94)(85-87)(85-89)(85-95)(86-88)(86-90)(86-96)(89-97)(90-97)(93-97)(94-97)
Measurements (14)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HL60 | 0.01 | — | 10.1016/j.jinorgbio.2019.11075... | 2019 |
| HL60 | 0.01 | — | 10.1038/s41598-019-47914-x | 2019 |
| K-562 | 0.2 | — | 10.1016/j.jinorgbio.2019.11075... | 2019 |
| K-562 | 0.2 | — | 10.1038/s41598-019-47914-x | 2019 |
| B16-F10 | 0.81 | — | 10.1016/j.jinorgbio.2019.11075... | 2019 |
| B16-F10 | 0.83 | — | 10.1038/s41598-019-47914-x | 2019 |
| HepG2 | 0.95 | — | 10.1038/s41598-019-47914-x | 2019 |
| HepG2 | 0.98 | — | 10.1016/j.jinorgbio.2019.11075... | 2019 |
| HCT-116 | 1.4 | — | 10.1038/s41598-019-47914-x | 2019 |
| SCC-4 | 1.6 | — | 10.1038/s41598-019-47914-x | 2019 |
| PBMC | 2.5 | — | 10.1016/j.jinorgbio.2019.11075... | 2019 |
| PBMC | 2.6 | — | 10.1038/s41598-019-47914-x | 2019 |
| HSC-3 | 4.4 | — | 10.1038/s41598-019-47914-x | 2019 |
| MRC-5 | 5.7 | — | 10.1038/s41598-019-47914-x | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«cotreatment with a pan-caspase inhibitor (Z-VAD(OMe)-FMK) reduced the apoptosis caused by both complexes, indicating a caspase-mediated apoptotic cell death.»