Info
| ID | 2174 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | Ru |
| SMILES | O=C(O)c1ccnc(-c2cc(C(=O)O)ccn2)c1.O=C(O)c1ccnc(-c2cc(C(=O)O)ccn2)c1.c1csc(-c2ccc(-c3ccc(-c4nc5c6cccnc6c6ncccc6c5[nH]4)s3)s2)c1 |
TUCAN
C49H30N8O8RuS3/(1-44)(2-42)(3-32)(4-37)(5-58)(6-39)(7-46)(8-56)(9-35)(10-55)(11-33)(12-38)(13-40)(14-57)(15-41)(16-59)(17-43)(18-31)(19-36)(20-45)(21-74)(22-34)(23-60)(24-48)(25-47)(26-81)(27-94)(28-92)(29-93)(30-95)(31-49)(31-55)(32-34)(32-74)(33-36)(33-75)(34-78)(35-49)(35-63)(36-77)(37-46)(37-76)(38-44)(38-56)(39-54)(39-57)(40-54)(40-62)(41-42)(41-52)(42-58)(43-50)(43-66)(44-53)(45-50)(45-59)(46-79)(47-51)(47-64)(48-51)(48-60)(49-70)(50-72)(51-71)(52-65)(52-68)(53-61)(53-67)(54-73)(55-85)(56-83)(57-84)(58-80)(59-86)(60-87)(61-65)(61-83)(62-64)(62-84)(63-66)(63-85)(64-87)(65-80)(66-86)(67-68)(67-82)(68-81)(69-76)(69-81)(69-82)(70-88)(70-92)(71-90)(71-94)(72-89)(72-93)(73-91)(73-95)(74-98)(75-79)(75-96)(76-97)(77-78)(77-96)(78-98)(79-97)(82-99)(83-99)(84-99)(85-99)(86-99)(87-99)(94-99)(95-99)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HN6 | — | 0.25 | 10.1016/j.biomaterials.2022.12... | 2022 |
| HSC-6 | — | 0.28 | 10.1016/j.biomaterials.2022.12... | 2022 |
| DOK | — | 0.24 | 10.1016/j.biomaterials.2022.12... | 2022 |
🧬 Cell Death Types (1)
Pyroptosis
high
«As a consequence of hypoxia relief and pyroptosis induction, TiO2@Ru@siRNA reshapes the immune microenvironment»