Info
| ID | 2163 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 3, "P": 2} |
| Abbreviation | [Ru(dicl)(dppp)(bpy)]PF6 |
| SMILES | O=C([O-])Cc1ccccc1Nc1c(Cl)cccc1Cl.c1ccc(-c2ccccn2)nc1.c1ccc(P(CCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C51H44Cl2N3O2P2Ru/(1-46)(2-88)(3-45)(4-49)(5-81)(6-88)(7-57)(8-78)(9-47)(10-59)(11-60)(12-48)(13-79)(14-51)(15-89)(16-78)(17-50)(18-55)(19-56)(20-89)(21-79)(22-62)(23-52)(24-82)(25-58)(26-63)(27-64)(28-67)(29-65)(30-66)(31-68)(32-72)(33-70)(34-54)(35-69)(36-73)(37-74)(38-76)(39-53)(40-75)(41-61)(42-77)(43-71)(44-96)(45-46)(45-48)(46-49)(47-57)(47-59)(48-90)(49-50)(50-90)(51-72)(51-83)(52-62)(52-80)(53-71)(53-94)(54-74)(54-84)(55-57)(55-91)(56-59)(56-91)(58-60)(58-92)(60-67)(61-62)(61-75)(63-64)(63-92)(64-67)(65-66)(65-93)(66-70)(68-69)(68-70)(69-93)(71-77)(72-73)(73-81)(74-76)(75-86)(76-82)(77-95)(78-88)(78-89)(79-80)(79-87)(80-86)(81-97)(82-98)(83-84)(83-97)(84-98)(85-94)(85-95)(85-96)(86-96)(87-99)(87-100)(88-101)(89-102)(90-101)(91-101)(92-102)(93-102)(94-103)(95-104)(97-105)(98-105)(101-105)(102-105)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MRC-5 | 1 | — | 10.1039/d0dt01591a | 2020 |
| MCF-7 | 1.5 | — | 10.1039/d0dt01591a | 2020 |
| MDA-MB-231 | 3.6 | — | 10.1039/d0dt01591a | 2020 |
| MCF-10A | 6.5 | — | 10.1039/d0dt01591a | 2020 |
| A549 | 12 | — | 10.1039/d0dt01591a | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«The apoptosis assay demonstrates that the complex (1) induces programmed cell death in MCF-7 cell lines.»