Info
| ID | 2162 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 3, "P": 2} |
| Abbreviation | [Ru(dicl)(dppe)(bpy)]PF6 |
| SMILES | O=C([O-])Cc1ccccc1Nc1c(Cl)cccc1Cl.c1ccc(-c2ccccn2)nc1.c1ccc(P(CCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C50H42Cl2N3O2P2Ru/(1-55)(2-85)(3-44)(4-61)(5-78)(6-43)(7-45)(8-85)(9-57)(10-49)(11-54)(12-46)(13-76)(14-74)(15-86)(16-86)(17-79)(18-62)(19-47)(20-48)(21-64)(22-76)(23-59)(24-51)(25-60)(26-56)(27-63)(28-67)(29-66)(30-68)(31-70)(32-50)(33-65)(34-72)(35-69)(36-53)(37-52)(38-73)(39-58)(40-75)(41-71)(42-93)(43-44)(43-87)(44-55)(45-46)(45-55)(46-87)(47-49)(47-88)(48-54)(48-88)(49-57)(50-60)(50-80)(51-59)(51-77)(52-71)(52-91)(53-72)(53-81)(54-57)(56-64)(56-89)(58-59)(58-73)(60-61)(61-78)(62-64)(62-67)(63-67)(63-89)(65-68)(65-70)(66-68)(66-90)(69-70)(69-90)(71-75)(72-74)(73-83)(74-79)(75-92)(76-77)(76-84)(77-83)(78-94)(79-95)(80-81)(80-94)(81-95)(82-91)(82-92)(82-93)(83-93)(84-96)(84-97)(85-86)(85-98)(86-99)(87-98)(88-98)(89-99)(90-99)(91-100)(92-101)(94-102)(95-102)(98-102)(99-102)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MRC-5 | 1.8 | — | 10.1039/d0dt01591a | 2020 |
| MCF-7 | 3.1 | — | 10.1039/d0dt01591a | 2020 |
| MDA-MB-231 | 3.6 | — | 10.1039/d0dt01591a | 2020 |
| A549 | 3.6 | — | 10.1039/d0dt01591a | 2020 |
| MCF-10A | 5.5 | — | 10.1039/d0dt01591a | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«The apoptosis assay demonstrates that the complex (1) induces programmed cell death in MCF-7 cell lines.»