Info
| ID | 2161 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 3, "P": 2} |
| Abbreviation | [Ru(dicl)(dppb)(bpy)]PF6 |
| SMILES | O=C([O-])Cc1ccccc1Nc1c(Cl)cccc1Cl.c1ccc(-c2ccccn2)nc1.c1ccc(P(CCCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C52H46Cl2N3O2P2Ru/(1-52)(2-91)(3-47)(4-58)(5-91)(6-80)(7-48)(8-80)(9-63)(10-51)(11-59)(12-49)(13-82)(14-74)(15-92)(16-81)(17-92)(18-50)(19-53)(20-81)(21-82)(22-62)(23-55)(24-60)(25-65)(26-64)(27-66)(28-68)(29-67)(30-70)(31-71)(32-84)(33-69)(34-75)(35-72)(36-85)(37-54)(38-57)(39-76)(40-78)(41-56)(42-77)(43-61)(44-79)(45-73)(46-99)(47-49)(47-52)(48-50)(48-52)(49-93)(50-93)(51-53)(51-58)(53-94)(54-74)(54-86)(55-62)(55-83)(56-73)(56-97)(57-76)(57-87)(58-59)(59-60)(60-94)(61-62)(61-77)(63-64)(63-68)(64-65)(65-95)(66-68)(66-95)(67-70)(67-96)(69-70)(69-71)(71-72)(72-96)(73-79)(74-75)(75-84)(76-78)(77-89)(78-85)(79-98)(80-81)(80-91)(81-92)(82-83)(82-90)(83-89)(84-100)(85-101)(86-87)(86-100)(87-101)(88-97)(88-98)(88-99)(89-99)(90-102)(90-103)(91-104)(92-105)(93-104)(94-104)(95-105)(96-105)(97-106)(98-107)(100-108)(101-108)(104-108)(105-108)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MRC-5 | 0.56 | — | 10.1039/d0dt01591a | 2020 |
| MCF-7 | 0.87 | — | 10.1039/d0dt01591a | 2020 |
| MDA-MB-231 | 1.6 | — | 10.1039/d0dt01591a | 2020 |
| A549 | 4.3 | — | 10.1039/d0dt01591a | 2020 |
| MCF-10A | 4.4 | — | 10.1039/d0dt01591a | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«The apoptosis assay demonstrates that the complex (1) induces programmed cell death in MCF-7 cell lines.»