Info
| ID | 2154 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2, "O": 1} |
| Abbreviation | 6 |
| SMILES | Cc1cc(NC(=S)NC(=O)c2ccco2)c([N+](=O)[O-])cc1C.Cc1ccc(C(C)C)cc1.[Cl-].[Cl-] |
TUCAN
C24Cl2N3O4RuS/(1-14)(2-16)(3-17)(4-17)(5-18)(6-18)(6-20)(7-8)(7-15)(8-14)(9-12)(9-22)(10-16)(10-19)(11-13)(11-15)(12-21)(13-14)(15-17)(16-18)(19-20)(19-27)(20-26)(21-29)(22-23)(22-29)(23-25)(23-28)(24-25)(24-26)(24-32)(27-30)(27-31)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| T47D | 8.5 | — | 10.1021/acs.inorgchem.3c00757 | 2023 |
| MDA-MB-231 | 8.6 | — | 10.1021/acs.inorgchem.3c00757 | 2023 |
| MCF-7 | 9.8 | — | 10.1021/acs.inorgchem.3c00757 | 2023 |
| MCF-10A | — | — | 10.1021/acs.inorgchem.3c00757 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«The most active complexes were tested for their mode of cell death through staining assays, which confirmed apoptosis. The upregulation of apoptotic inducing and downregulation of apoptotic suppressin...»