Info
| ID | 2131 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 2 |
| SMILES | Cc1ccnc(-c2cc(C)ccn2)c1.Cc1ccnc(-c2cc(C)ccn2)c1.Oc1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1Br |
TUCAN
C43H35BrN8ORu/(1-36)(2-67)(3-62)(4-36)(5-64)(6-41)(7-51)(8-40)(9-36)(10-63)(11-52)(12-49)(13-37)(14-65)(15-50)(16-42)(17-66)(18-37)(19-47)(20-37)(21-38)(22-44)(23-38)(24-53)(25-45)(26-46)(27-38)(28-43)(29-48)(30-54)(31-39)(32-39)(33-39)(34-80)(35-87)(36-57)(37-58)(38-60)(39-61)(40-57)(40-62)(41-57)(41-71)(42-60)(42-63)(43-46)(43-56)(44-45)(44-55)(45-67)(46-77)(47-58)(47-65)(48-56)(48-78)(49-50)(49-64)(50-59)(51-58)(51-72)(52-60)(52-73)(53-61)(53-66)(54-61)(54-74)(55-68)(55-69)(56-76)(59-70)(59-75)(62-81)(63-83)(64-82)(65-84)(66-86)(67-79)(68-70)(68-79)(69-75)(69-80)(70-82)(71-72)(71-81)(72-84)(73-74)(73-83)(74-86)(75-85)(76-80)(76-85)(77-78)(77-87)(78-88)(81-89)(82-89)(83-89)(84-89)(85-89)(86-89)(87-89)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 13 | — | 10.1080/00958972.2012.680592 | 2015 |
| MCF-7 | 16 | — | 10.1080/00958972.2012.680592 | 2015 |
| BEL-7402 | 17 | — | 10.1080/00958972.2012.680592 | 2015 |
| MG-63 | 17 | — | 10.1080/00958972.2012.680592 | 2015 |
🧬 Cell Death Types (1)
Apoptosis
high
«In the presence of 1 (b) and 2 (c) (Supplementary material), the percentage of apoptosis (A) and necrotosis (N) of BEL-7402 cells was 37.64% and 7.33% for 1 and 16.52% and 0.46% for 2. Cell apoptosis ...»