Info
| ID | 2130 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 1 |
| SMILES | Cc1ccc2ccc3ccc(C)nc3c2n1.Cc1ccc2ccc3ccc(C)nc3c2n1.Oc1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1Br |
TUCAN
C47H35BrN8ORu/(1-36)(2-36)(3-36)(4-37)(5-66)(6-53)(7-37)(8-37)(9-40)(10-38)(11-38)(12-41)(13-52)(14-67)(15-38)(16-39)(17-39)(18-39)(19-43)(20-47)(21-42)(22-44)(23-54)(24-46)(25-48)(26-50)(27-45)(28-51)(29-55)(30-57)(31-58)(32-49)(33-56)(34-84)(35-91)(36-68)(37-72)(38-77)(39-79)(40-42)(40-68)(41-49)(41-72)(42-60)(43-48)(43-60)(44-50)(44-61)(45-46)(45-59)(46-81)(47-53)(47-62)(48-61)(49-63)(50-77)(51-59)(51-82)(52-54)(52-67)(53-66)(54-64)(55-57)(55-63)(56-58)(56-65)(57-65)(58-79)(59-80)(60-69)(61-70)(62-71)(62-74)(63-73)(64-75)(64-78)(65-76)(66-83)(67-90)(68-85)(69-70)(69-85)(70-87)(71-78)(71-84)(72-86)(73-76)(73-86)(74-75)(74-83)(75-90)(76-88)(77-87)(78-89)(79-88)(80-84)(80-89)(81-82)(81-91)(82-92)(85-93)(86-93)(87-93)(88-93)(89-93)(90-93)(91-93)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MG-63 | 19 | — | 10.1080/00958972.2012.680592 | 2015 |
| BEL-7402 | 26 | — | 10.1080/00958972.2012.680592 | 2015 |
| HeLa | 28 | — | 10.1080/00958972.2012.680592 | 2015 |
| MCF-7 | 39 | — | 10.1080/00958972.2012.680592 | 2015 |
🧬 Cell Death Types (1)
Apoptosis
high
«In the presence of 1 (b) and 2 (c) (Supplementary material), the percentage of apoptosis (A) and necrotosis (N) of BEL-7402 cells was 37.64% and 7.33% for 1 and 16.52% and 0.46% for 2. Cell apoptosis ...»