Info
| ID | 2007 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | Ru3 |
| SMILES | [Cl-].c1ccc(-c2ccc(-c3cc(-c4ccccn4)nc(-c4ccccn4)c3)cc2)cc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C37H27N5Ru/(1-44)(2-42)(3-58)(4-31)(5-32)(6-34)(7-28)(8-56)(9-55)(10-57)(11-30)(12-50)(13-35)(14-39)(15-33)(16-29)(17-49)(18-37)(19-40)(20-38)(21-36)(22-48)(23-41)(24-45)(25-43)(26-46)(27-47)(28-40)(28-54)(29-34)(29-35)(30-31)(30-32)(31-59)(32-55)(33-46)(33-60)(34-52)(35-45)(36-45)(36-52)(37-42)(37-62)(38-43)(38-56)(39-43)(39-63)(40-53)(41-48)(41-53)(42-49)(44-51)(44-61)(46-47)(47-57)(48-54)(49-58)(50-51)(50-64)(51-53)(52-54)(55-66)(56-65)(57-69)(58-67)(59-60)(59-66)(60-69)(61-62)(61-68)(62-67)(63-64)(63-65)(64-68)(66-70)(67-70)(68-70)(69-70)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 3.3 | — | 10.1039/c5dt02446c | 2015 |
| A549 | 3.7 | — | 10.1039/c5dt02446c | 2015 |
| A549cisR | 4.1 | — | 10.1039/c5dt02446c | 2015 |
| HepG2 | 5.6 | — | 10.1039/c5dt02446c | 2015 |
| BEL-7402 | 7.4 | — | 10.1039/c5dt02446c | 2015 |
| LO2 | 10 | — | 10.1039/c5dt02446c | 2015 |
🧬 Cell Death Types (1)
Apoptosis
high
«Antiproliferative assay revealed that Ru3 significantly inhibited cellular DNA replication which induced ultimately apoptosis of cancer cells.»