Info
| ID | 2006 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | Ru2 |
| SMILES | [Cl-].c1ccc(-c2cc(-c3ccccn3)nc(-c3ccccn3)c2)cc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C31H23N5Ru/(1-24)(2-48)(3-25)(4-26)(5-35)(6-46)(7-45)(8-47)(9-28)(10-42)(11-30)(12-33)(13-27)(14-41)(15-29)(16-32)(17-31)(18-37)(19-34)(20-40)(21-36)(22-38)(23-39)(24-29)(24-30)(25-28)(25-49)(26-28)(26-45)(27-38)(27-50)(29-37)(30-43)(31-35)(31-52)(32-36)(32-46)(33-36)(33-53)(34-37)(34-43)(35-41)(38-39)(39-47)(40-44)(40-51)(41-48)(42-44)(42-54)(43-44)(45-56)(46-55)(47-59)(48-57)(49-50)(49-56)(50-59)(51-52)(51-58)(52-57)(53-54)(53-55)(54-58)(56-60)(57-60)(58-60)(59-60)
Measurements (12)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| BEL-7402 | 45 | — | 10.1039/c5dt02446c | 2015 |
| HeLa | 51 | — | 10.1039/c5dt02446c | 2015 |
| HepG2 | 69 | — | 10.1039/c5dt02446c | 2015 |
| A549 | 79 | — | 10.1039/c5dt02446c | 2015 |
| A549 | 94 | — | 10.1016/j.biomaterials.2017.03... | 2017 |
| HeLa | 94 | 6.8 | 10.1021/acs.inorgchem.4c00650 | 2024 |
| LO2 | — | — | 10.1039/c5dt02446c | 2015 |
| A549cisR | — | — | 10.1039/c5dt02446c | 2015 |
| A375 | — | — | 10.1016/j.biomaterials.2017.03... | 2017 |
| MCF-7 | — | — | 10.1016/j.biomaterials.2017.03... | 2017 |
| HepG2 | — | — | 10.1016/j.biomaterials.2017.03... | 2017 |
| HK-2 | — | — | 10.1016/j.biomaterials.2017.03... | 2017 |
🧬 Cell Death Types (1)
Apoptosis
high
«Antiproliferative assay revealed that Ru3 significantly inhibited cellular DNA replication which induced ultimately apoptosis of cancer cells.»
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