Info
| ID | 2 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1} |
| Abbreviation | Ru-Cur |
| SMILES | COc1cc(/C=C/C(=O)/C=C([O-])/C=C/c2ccc(O)c(OC)c2)ccc1O.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C31ClO6Ru/(1-21)(2-22)(3-21)(4-9)(4-20)(5-6)(5-19)(6-22)(7-10)(7-23)(8-12)(8-20)(9-27)(10-30)(11-18)(11-19)(12-28)(13-15)(13-29)(14-20)(14-26)(15-23)(16-23)(16-31)(17-28)(17-29)(18-22)(19-21)(24-36)(25-37)(26-27)(26-36)(27-33)(28-32)(29-35)(30-31)(30-34)(31-37)
Measurements (18)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 14 | — | 10.1021/jm200912j | 2012 |
| HCT-116 | 14 | — | 10.1016/j.jinorgbio.2016.06.00... | 2016 |
| HeLa | 15 | — | 10.1021/acs.inorgchem.2c01005 | 2022 |
| HCT-116 | 16 | — | 10.1021/acs.inorgchem.2c01005 | 2022 |
| HeLa | 16 | — | 10.1039/c8cc01584h | 2018 |
| HepG2 | 17 | — | 10.1021/acs.inorgchem.2c01005 | 2022 |
| MCF-7 | 20 | — | 10.1021/jm200912j | 2012 |
| MCF-7 | 20 | — | 10.1016/j.jinorgbio.2016.06.00... | 2016 |
| A2780 | 23 | — | 10.1021/jm200912j | 2012 |
| A2780 | 23 | — | 10.1016/j.jinorgbio.2016.06.00... | 2016 |
| CP8 | 27 | — | 10.1021/jm200912j | 2012 |
| U-87 MG | 29 | — | 10.1021/jm200912j | 2012 |
| HepG2 | 47 | — | 10.1002/aoc.3685 | 2016 |
| HEK293T | 49 | — | 10.1002/aoc.3685 | 2016 |
| HeLa | 52 | — | 10.1002/aoc.3685 | 2016 |
| U-87 MG | 62 | — | 10.1016/j.jinorgbio.2016.06.00... | 2016 |
| A549 | 62 | — | 10.1021/jm200912j | 2012 |
| A549 | 63 | — | 10.1016/j.jinorgbio.2016.06.00... | 2016 |
🧬 Cell Death Types (1)
Apoptosis
medium
«the addition of TB-Ru-Cur to HepG2 cells seems to harm the cell integrity, where the extracellular membrane is 'blebbing' up, suggesting that cells undergo apoptosis and necrosis»