Info
| ID | 1981 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | RDC41 |
| SMILES | Nc1cc[c-]c(-c2ccccn2)c1.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C35H25N6Ru/(1-29)(2-30)(3-27)(4-28)(5-36)(6-50)(7-44)(8-43)(9-34)(10-42)(11-37)(12-51)(13-53)(14-38)(15-33)(16-39)(17-41)(18-31)(19-32)(20-54)(21-40)(22-52)(23-35)(24-61)(25-61)(26-43)(26-49)(27-29)(27-50)(28-30)(28-51)(29-45)(30-46)(31-33)(31-47)(32-39)(32-48)(33-53)(34-35)(34-42)(35-52)(36-37)(36-45)(37-46)(38-40)(38-47)(39-54)(40-48)(41-49)(41-56)(42-60)(43-44)(44-56)(45-55)(46-57)(47-58)(48-59)(49-60)(50-62)(51-63)(52-66)(53-64)(54-65)(55-57)(55-62)(56-61)(57-63)(58-59)(58-64)(59-65)(60-66)(62-67)(63-67)(64-67)(65-67)(66-67)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 3 | — | 10.1016/j.bcp.2012.08.022 | 2012 |
| HCT-116 | 5 | — | 10.1039/c1dt10322a | 2011 |
🧬 Cell Death Types (1)
Apoptosis
high
«RDC34 was as efficient as RDC11 to induce CHOP, but was more potent to induce p53 protein levels... RDC34 increased the expression of pro-apoptotic p53 target genes... RDC34 was more potent in inducin...»