Info
| ID | 1980 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 5} |
| Abbreviation | RDC40 |
| SMILES | O=[N+]([O-])c1cc[c-]c(-c2ccccn2)c1.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C35H23N6O2Ru/(1-48)(2-30)(3-33)(4-27)(5-38)(6-28)(7-49)(8-25)(9-35)(10-34)(11-26)(12-36)(13-37)(14-39)(15-50)(16-29)(17-32)(18-41)(19-31)(20-51)(21-40)(22-52)(23-42)(24-34)(24-47)(25-30)(25-43)(26-36)(26-42)(27-28)(27-43)(28-44)(29-31)(29-45)(30-48)(31-46)(32-47)(32-58)(33-39)(33-49)(34-35)(35-58)(36-56)(37-41)(37-44)(38-40)(38-50)(39-45)(40-46)(41-51)(42-52)(43-53)(44-54)(45-55)(46-57)(47-56)(48-60)(49-61)(50-62)(51-63)(52-64)(53-54)(53-60)(54-63)(55-57)(55-61)(56-64)(57-62)(58-59)(59-65)(59-66)(60-67)(61-67)(62-67)(63-67)(64-67)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 0.5 | — | 10.1039/c1dt10322a | 2011 |
| HCT-116 | 0.75 | — | 10.1016/j.bcp.2012.08.022 | 2012 |
🧬 Cell Death Types (1)
Apoptosis
high
«RDC34 was as efficient as RDC11 to induce CHOP, but was more potent to induce p53 protein levels... RDC34 increased the expression of pro-apoptotic p53 target genes... RDC34 was more potent in inducin...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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