Info
| ID | 1852 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 6 |
| SMILES | O=C1c2ccccc2C(=O)c2c1cccc2-c1cc(-c2nccs2)nc(-c2nccs2)c1.c1cc(-c2nc3ccccc3[nH]2)nc(-c2nc3ccccc3[nH]2)c1 |
TUCAN
C44H26N8O2RuS2/(1-27)(2-40)(3-43)(4-28)(5-46)(6-41)(7-31)(8-35)(9-33)(10-29)(11-36)(12-45)(13-68)(14-37)(15-67)(16-44)(17-54)(18-32)(19-38)(20-30)(21-42)(22-39)(23-34)(24-53)(25-74)(26-73)(27-28)(27-35)(28-58)(29-34)(29-55)(30-31)(30-56)(31-33)(32-34)(32-38)(33-60)(35-37)(36-52)(36-62)(37-57)(38-61)(39-52)(39-59)(40-41)(40-50)(41-45)(42-46)(42-51)(43-46)(43-48)(44-45)(44-49)(47-48)(47-51)(47-66)(48-65)(49-50)(49-65)(50-66)(51-52)(53-68)(53-71)(54-67)(54-76)(55-61)(55-75)(56-63)(56-77)(57-58)(57-72)(58-73)(59-70)(59-78)(60-64)(60-77)(61-74)(62-69)(62-78)(63-74)(63-75)(64-72)(64-73)(65-80)(66-79)(67-81)(68-82)(69-71)(69-82)(70-76)(70-81)(75-83)(76-83)(77-83)(78-83)(81-83)(82-83)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 22 | — | 10.1002/chem.201502154 | 2015 |
| A549 | 25 | — | 10.1002/chem.201502154 | 2015 |
| A549cisR | 28 | — | 10.1002/chem.201502154 | 2015 |
| LO2 | 30 | — | 10.1002/chem.201502154 | 2015 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further mechanistic studies show that complex 1 induced cell apoptosis during hypoxia through multiple pathways»