Info
| ID | 1851 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 5 |
| SMILES | O=C1c2ccccc2C(=O)c2c1cccc2-c1cc(-c2ccccn2)nc(-c2ccccn2)c1.c1cc(-c2nc3ccccc3[nH]2)nc(-c2nc3ccccc3[nH]2)c1 |
TUCAN
C48H30N8O2Ru/(1-47)(2-52)(3-41)(4-35)(5-45)(6-48)(7-42)(8-46)(9-39)(10-64)(11-37)(12-38)(13-55)(14-49)(15-56)(16-31)(17-40)(18-44)(19-43)(20-50)(21-54)(22-63)(23-36)(24-33)(25-51)(26-53)(27-32)(28-34)(29-82)(30-81)(31-33)(31-35)(32-51)(32-63)(33-34)(34-65)(35-66)(36-38)(36-43)(37-38)(37-71)(39-40)(39-57)(40-42)(41-48)(41-73)(42-60)(43-72)(44-45)(44-47)(45-67)(46-61)(46-69)(47-70)(48-56)(49-50)(49-62)(50-54)(51-55)(52-61)(52-74)(53-54)(53-58)(55-68)(56-64)(57-59)(57-77)(58-62)(58-77)(59-60)(59-78)(60-61)(62-78)(63-79)(64-86)(65-66)(65-81)(66-83)(67-76)(67-84)(68-69)(68-79)(69-85)(70-75)(70-84)(71-72)(71-80)(72-82)(73-74)(73-86)(74-85)(75-81)(75-83)(76-80)(76-82)(77-87)(78-88)(83-89)(84-89)(85-89)(86-89)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 18 | — | 10.1002/chem.201502154 | 2015 |
| A549cisR | 22 | — | 10.1002/chem.201502154 | 2015 |
| A549 | 26 | — | 10.1002/chem.201502154 | 2015 |
| LO2 | 27 | — | 10.1002/chem.201502154 | 2015 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further mechanistic studies show that complex 1 induced cell apoptosis during hypoxia through multiple pathways»