Info
| ID | 1850 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 4 |
| SMILES | O=C1c2ccccc2C(=O)c2c1cccc2-c1cc(-c2nccs2)nc(-c2nccs2)c1.c1ccc(-c2cccc(-c3ccccn3)n2)nc1 |
TUCAN
C40H24N6O2RuS2/(1-31)(2-25)(3-37)(4-29)(5-42)(6-62)(7-52)(8-61)(9-26)(10-35)(11-50)(12-34)(13-27)(14-49)(15-51)(16-40)(17-38)(18-39)(19-33)(20-41)(21-32)(22-36)(23-30)(24-28)(25-45)(25-53)(26-28)(26-50)(27-28)(27-57)(29-31)(29-49)(30-34)(30-36)(31-35)(32-40)(32-43)(33-45)(33-58)(34-56)(35-55)(36-54)(37-42)(37-44)(38-41)(38-48)(39-41)(39-47)(40-42)(43-44)(43-60)(44-59)(45-47)(46-47)(46-48)(46-60)(48-59)(49-68)(50-65)(51-61)(51-70)(52-62)(52-66)(53-63)(53-67)(54-57)(54-69)(55-56)(55-68)(56-69)(57-65)(58-64)(58-67)(59-71)(60-72)(61-74)(62-73)(63-66)(63-73)(64-70)(64-74)(67-75)(68-75)(69-75)(70-75)(73-75)(74-75)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 1.1e+02 | — | 10.1002/chem.201502154 | 2015 |
| A549 | 1.1e+02 | — | 10.1002/chem.201502154 | 2015 |
| A549cisR | 1.1e+02 | — | 10.1002/chem.201502154 | 2015 |
| LO2 | 1.3e+02 | — | 10.1002/chem.201502154 | 2015 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further mechanistic studies show that complex 1 induced cell apoptosis during hypoxia through multiple pathways»