Info
| ID | 1849 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 3 |
| SMILES | O=C1c2ccccc2C(=O)c2c1cccc2-c1cc(-c2ccccn2)nc(-c2ccccn2)c1.c1ccc(-c2cccc(-c3ccccn3)n2)nc1 |
TUCAN
C44H28N6O2Ru/(1-62)(2-35)(3-39)(4-47)(5-34)(6-61)(7-42)(8-51)(9-36)(10-30)(11-48)(12-50)(13-37)(14-38)(15-59)(16-40)(17-31)(18-45)(19-52)(20-43)(21-33)(22-41)(23-60)(24-29)(25-49)(26-46)(27-44)(28-32)(29-30)(29-67)(30-33)(31-32)(31-46)(32-64)(33-60)(34-35)(34-63)(35-36)(36-61)(37-44)(37-68)(38-44)(38-62)(39-51)(39-58)(40-57)(40-69)(41-48)(41-51)(42-47)(42-52)(43-50)(43-59)(45-57)(45-70)(46-65)(47-54)(48-55)(49-50)(49-66)(52-56)(53-54)(53-56)(53-72)(54-71)(55-58)(55-71)(56-57)(58-72)(59-78)(60-74)(61-73)(62-75)(63-64)(63-73)(64-77)(65-68)(65-77)(66-69)(66-78)(67-70)(67-74)(68-75)(69-76)(70-76)(71-80)(72-79)(75-81)(76-81)(77-81)(78-81)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 97 | — | 10.1002/chem.201502154 | 2015 |
| A549cisR | 1.1e+02 | — | 10.1002/chem.201502154 | 2015 |
| A549 | 1.1e+02 | — | 10.1002/chem.201502154 | 2015 |
| LO2 | 1.2e+02 | — | 10.1002/chem.201502154 | 2015 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further mechanistic studies show that complex 1 induced cell apoptosis during hypoxia through multiple pathways»