Info
| ID | 1848 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | 2 |
| SMILES | O=C1c2ccccc2C(=O)c2c1cccc2-c1cc(-c2nccs2)nc(-c2nccs2)c1.[c-]1ccccc1-c1cccc(-c2ccccn2)n1 |
TUCAN
C41H24N5O2RuS2/(1-32)(2-43)(3-35)(4-30)(5-44)(6-34)(7-40)(8-62)(9-27)(10-39)(11-53)(12-31)(13-38)(14-28)(15-26)(16-52)(17-36)(18-37)(19-33)(20-63)(21-54)(22-42)(23-29)(24-41)(25-38)(25-45)(26-30)(26-53)(27-28)(27-38)(28-29)(29-45)(30-32)(31-39)(31-41)(32-58)(33-34)(33-48)(34-36)(35-44)(35-47)(36-43)(37-50)(37-56)(39-59)(40-50)(40-57)(41-55)(42-44)(42-51)(43-49)(45-55)(46-47)(46-51)(46-60)(47-61)(48-49)(48-61)(49-60)(50-51)(52-62)(52-66)(53-68)(54-63)(54-70)(55-67)(56-64)(56-69)(57-65)(57-69)(58-59)(58-68)(59-67)(60-72)(61-71)(62-73)(63-74)(64-70)(64-74)(65-66)(65-73)(67-75)(68-75)(69-75)(70-75)(74-75)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 1.1 | — | 10.1002/chem.201502154 | 2015 |
| A549 | 1.4 | — | 10.1002/chem.201502154 | 2015 |
| A549cisR | 2.3 | — | 10.1002/chem.201502154 | 2015 |
| LO2 | 5 | — | 10.1002/chem.201502154 | 2015 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further mechanistic studies show that complex 1 induced cell apoptosis during hypoxia through multiple pathways»