Info
| ID | 1847 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | 1 |
| SMILES | O=C1c2ccccc2C(=O)c2c1cccc2-c1cc(-c2ccccn2)nc(-c2ccccn2)c1.[c-]1ccccc1-c1cccc(-c2ccccn2)n1 |
TUCAN
C45H28N5O2Ru/(1-52)(2-35)(3-47)(4-54)(5-34)(6-64)(7-46)(8-41)(9-43)(10-36)(11-30)(12-48)(13-49)(14-32)(15-38)(16-50)(17-42)(18-53)(19-31)(20-44)(21-51)(22-40)(23-39)(24-63)(25-45)(26-62)(27-33)(28-37)(29-39)(29-57)(30-61)(30-71)(31-33)(31-65)(32-33)(32-66)(34-35)(34-57)(35-36)(36-39)(37-38)(37-69)(38-52)(40-43)(40-59)(41-42)(41-58)(42-45)(43-44)(44-56)(45-48)(46-53)(46-54)(47-61)(47-68)(48-60)(49-50)(49-67)(50-51)(51-63)(52-64)(53-62)(54-70)(55-56)(55-59)(55-72)(56-61)(57-65)(58-60)(58-73)(59-73)(60-72)(62-77)(63-74)(64-75)(65-76)(66-69)(66-76)(67-71)(67-74)(68-70)(68-78)(69-75)(70-77)(71-78)(72-80)(73-79)(75-81)(76-81)(77-81)(78-81)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 0.51 | — | 10.1002/chem.201502154 | 2015 |
| A549 | 0.55 | — | 10.1002/chem.201502154 | 2015 |
| A549cisR | 0.57 | — | 10.1002/chem.201502154 | 2015 |
| LO2 | 4.5 | — | 10.1002/chem.201502154 | 2015 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further mechanistic studies show that complex 1 induced cell apoptosis during hypoxia through multiple pathways»