Info
| ID | 1811 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 1} |
| Abbreviation | 9 |
| SMILES | Cc1c(C)c(C)[c-](C)c1C.Nc1ccccc1 |
TUCAN
C16NRu/(1-11)(2-12)(3-13)(4-14)(5-15)(6-7)(6-16)(7-10)(8-9)(8-16)(9-10)(11-12)(11-13)(12-14)(13-15)(14-15)(16-17)
Measurements (25)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MM96L | 3.5 | — | 10.1002/asia.201100637 | 2012 |
| MM96L | 3.5 | — | 10.1021/ic801159f | 2008 |
| CI80-13S | 4.5 | — | 10.1002/asia.201100637 | 2012 |
| MCF-7 | 4.7 | — | 10.1002/asia.201100637 | 2012 |
| MCF-7 | 4.7 | — | 10.1021/ic801159f | 2008 |
| MM96L | 6.1 | — | 10.1021/ic801159f | 2008 |
| T47D | 9.1 | — | 10.1002/asia.201100637 | 2012 |
| MM96L | 9.3 | — | 10.1021/ic801159f | 2008 |
| MM418c5 | 10 | — | 10.1002/asia.201100637 | 2012 |
| MCF-7 | 11 | — | 10.1021/ic801159f | 2008 |
| MDA-MB-231 | 12 | — | 10.1002/asia.201100637 | 2012 |
| MDA-MB-231 | 12 | — | 10.1021/ic801159f | 2008 |
| DU-145 | 12 | — | 10.1002/asia.201100637 | 2012 |
| MCF-7 | 13 | — | 10.1021/ic801159f | 2008 |
| PC-3 | 14 | — | 10.1002/asia.201100637 | 2012 |
| MDA-MB-231 | 25 | — | 10.1021/ic801159f | 2008 |
| RAW 264.7 | 27 | — | 10.1002/asia.201100637 | 2012 |
| MDA-MB-231 | 31 | — | 10.1021/ic801159f | 2008 |
| A549 | 36 | — | 10.1002/asia.201100637 | 2012 |
| B16 | 36 | — | 10.1002/asia.201100637 | 2012 |
| HT-29 | 38 | — | 10.1002/asia.201100637 | 2012 |
| NFF | 98 | — | 10.1002/asia.201100637 | 2012 |
| NFF | 98 | — | 10.1021/ic801159f | 2008 |
| NFF | 1.8e+02 | — | 10.1021/ic801159f | 2008 |
| NFF | 1.9e+02 | — | 10.1021/ic801159f | 2008 |
🧬 Cell Death Types (1)
Apoptosis
high
«Mechanistic studies revealed that all complexes caused apoptosis induction by activating caspases with upregulation of Bax and downregulation of Bcl-2.»