Info
| ID | 1810 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1} |
| Abbreviation | 8 |
| SMILES | CCCC(=O)c1ccccc1.Cc1c(C)c(C)[c-](C)c1C |
TUCAN
C20ORu/(1-15)(2-16)(3-17)(4-18)(5-19)(6-12)(7-10)(7-14)(8-10)(8-11)(9-11)(9-14)(12-13)(13-20)(14-20)(15-16)(15-17)(16-18)(17-19)(18-19)(20-21)
Measurements (25)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| T47D | 1.8 | — | 10.1002/asia.201100637 | 2012 |
| MM96L | 2.9 | — | 10.1002/asia.201100637 | 2012 |
| MM96L | 2.9 | — | 10.1021/ic801159f | 2008 |
| CI80-13S | 2.9 | — | 10.1002/asia.201100637 | 2012 |
| MCF-7 | 3 | — | 10.1002/asia.201100637 | 2012 |
| MCF-7 | 3 | — | 10.1021/ic801159f | 2008 |
| PC-3 | 3.9 | — | 10.1002/asia.201100637 | 2012 |
| HT-29 | 4 | — | 10.1002/asia.201100637 | 2012 |
| DU-145 | 4.3 | — | 10.1002/asia.201100637 | 2012 |
| MM418c5 | 5.2 | — | 10.1002/asia.201100637 | 2012 |
| MM96L | 6.8 | — | 10.1021/ic801159f | 2008 |
| MM96L | 7.2 | — | 10.1021/ic801159f | 2008 |
| B16 | 8.6 | — | 10.1002/asia.201100637 | 2012 |
| MDA-MB-231 | 9.1 | — | 10.1002/asia.201100637 | 2012 |
| MDA-MB-231 | 9.1 | — | 10.1021/ic801159f | 2008 |
| A549 | 9.7 | — | 10.1002/asia.201100637 | 2012 |
| MCF-7 | 11 | — | 10.1021/ic801159f | 2008 |
| MCF-7 | 17 | — | 10.1021/ic801159f | 2008 |
| MDA-MB-231 | 30 | — | 10.1021/ic801159f | 2008 |
| RAW 264.7 | 30 | — | 10.1002/asia.201100637 | 2012 |
| MDA-MB-231 | 32 | — | 10.1021/ic801159f | 2008 |
| NFF | 33 | — | 10.1002/asia.201100637 | 2012 |
| NFF | 33 | — | 10.1021/ic801159f | 2008 |
| NFF | 1.3e+02 | — | 10.1021/ic801159f | 2008 |
| NFF | 1.4e+02 | — | 10.1021/ic801159f | 2008 |
🧬 Cell Death Types (1)
Apoptosis
high
«Mechanistic studies revealed that all complexes caused apoptosis induction by activating caspases with upregulation of Bax and downregulation of Bcl-2.»