Info
| ID | 1808 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 2} |
| Abbreviation | 6 |
| SMILES | CCCOC(=O)c1ccccc1.Cc1c(C)c(C)[c-](C)c1C |
TUCAN
C20O2Ru/(1-13)(2-14)(3-15)(4-17)(5-18)(6-11)(7-8)(7-9)(8-10)(9-16)(10-12)(11-19)(12-16)(13-14)(13-15)(14-17)(15-18)(16-20)(17-18)(19-22)(20-21)(20-22)
Measurements (25)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 2.3 | — | 10.1002/asia.201100637 | 2012 |
| MCF-7 | 2.3 | — | 10.1021/ic801159f | 2008 |
| MM96L | 2.5 | — | 10.1002/asia.201100637 | 2012 |
| MM96L | 2.5 | — | 10.1021/ic801159f | 2008 |
| CI80-13S | 2.7 | — | 10.1002/asia.201100637 | 2012 |
| T47D | 2.9 | — | 10.1002/asia.201100637 | 2012 |
| MDA-MB-231 | 3.4 | — | 10.1002/asia.201100637 | 2012 |
| MDA-MB-231 | 3.4 | — | 10.1021/ic801159f | 2008 |
| MM418c5 | 3.8 | — | 10.1002/asia.201100637 | 2012 |
| HT-29 | 4.2 | — | 10.1002/asia.201100637 | 2012 |
| DU-145 | 5 | — | 10.1002/asia.201100637 | 2012 |
| MM96L | 6.2 | — | 10.1021/ic801159f | 2008 |
| MM96L | 7.6 | — | 10.1021/ic801159f | 2008 |
| B16 | 8 | — | 10.1002/asia.201100637 | 2012 |
| PC-3 | 8.1 | — | 10.1002/asia.201100637 | 2012 |
| RAW 264.7 | 9.4 | — | 10.1002/asia.201100637 | 2012 |
| A549 | 10 | — | 10.1002/asia.201100637 | 2012 |
| NFF | 11 | — | 10.1002/asia.201100637 | 2012 |
| NFF | 11 | — | 10.1021/ic801159f | 2008 |
| MCF-7 | 12 | — | 10.1021/ic801159f | 2008 |
| MCF-7 | 14 | — | 10.1021/ic801159f | 2008 |
| MDA-MB-231 | 17 | — | 10.1021/ic801159f | 2008 |
| MDA-MB-231 | 18 | — | 10.1021/ic801159f | 2008 |
| NFF | 48 | — | 10.1021/ic801159f | 2008 |
| NFF | 56 | — | 10.1021/ic801159f | 2008 |
🧬 Cell Death Types (1)
Apoptosis
high
«Mechanistic studies revealed that all complexes caused apoptosis induction by activating caspases with upregulation of Bax and downregulation of Bcl-2.»