home← all complexes Ir builderC^N familiesD-MPNN

Complex #1808 — Ru(2) [6]

2D Structure

Structure
⬇ MOL V3000

Info

ID1808
MetalRu
Oxidation state2
Charge1
Donor atoms{"O": 2}
Abbreviation6
SMILESCCCOC(=O)c1ccccc1.Cc1c(C)c(C)[c-](C)c1C

TUCAN

C20O2Ru/(1-13)(2-14)(3-15)(4-17)(5-18)(6-11)(7-8)(7-9)(8-10)(9-16)(10-12)(11-19)(12-16)(13-14)(13-15)(14-17)(15-18)(16-20)(17-18)(19-22)(20-21)(20-22)

Measurements (25)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
MCF-72.3— 10.1002/asia.201100637 2012
MCF-72.3— 10.1021/ic801159f 2008
MM96L2.5— 10.1002/asia.201100637 2012
MM96L2.5— 10.1021/ic801159f 2008
CI80-13S2.7— 10.1002/asia.201100637 2012
T47D2.9— 10.1002/asia.201100637 2012
MDA-MB-2313.4— 10.1002/asia.201100637 2012
MDA-MB-2313.4— 10.1021/ic801159f 2008
MM418c53.8— 10.1002/asia.201100637 2012
HT-294.2— 10.1002/asia.201100637 2012
DU-1455— 10.1002/asia.201100637 2012
MM96L6.2— 10.1021/ic801159f 2008
MM96L7.6— 10.1021/ic801159f 2008
B168— 10.1002/asia.201100637 2012
PC-38.1— 10.1002/asia.201100637 2012
RAW 264.79.4— 10.1002/asia.201100637 2012
A54910— 10.1002/asia.201100637 2012
NFF11— 10.1002/asia.201100637 2012
NFF11— 10.1021/ic801159f 2008
MCF-712— 10.1021/ic801159f 2008
MCF-714— 10.1021/ic801159f 2008
MDA-MB-23117— 10.1021/ic801159f 2008
MDA-MB-23118— 10.1021/ic801159f 2008
NFF48— 10.1021/ic801159f 2008
NFF56— 10.1021/ic801159f 2008

🧬 Cell Death Types (1)

Apoptosis high
«Mechanistic studies revealed that all complexes caused apoptosis induction by activating caspases with upregulation of Bax and downregulation of Bcl-2.»

Source-assisted 2D generator

Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.

experimental validation surface
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The generated SVG will appear here. The legacy ligand image above stays visible for side-by-side review.