Info
| ID | 1804 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | 5c |
| SMILES | Brc1ccc2[nH]c3c(c2c1)C/C(=N\Cc1ccccn1)Nc1ccccc1-3.O=Cc1ccc(OCC(=O)NCc2ccccc2)cc1.[Cl-] |
TUCAN
C38H32BrN5O3Ru/(1-36)(2-59)(3-66)(4-35)(5-39)(6-40)(7-33)(8-59)(9-46)(10-50)(11-48)(12-51)(13-44)(14-45)(15-41)(16-67)(17-34)(18-43)(19-67)(20-37)(21-38)(22-60)(23-52)(24-60)(25-58)(26-47)(27-42)(28-49)(29-52)(30-71)(31-73)(32-72)(33-35)(33-37)(34-36)(34-68)(35-44)(36-53)(37-55)(38-44)(38-55)(39-46)(39-58)(40-41)(40-56)(41-47)(42-49)(42-63)(43-45)(43-68)(45-53)(46-50)(47-48)(48-62)(49-70)(50-61)(51-54)(51-70)(52-57)(52-65)(53-66)(54-57)(54-63)(55-59)(56-62)(56-64)(57-64)(58-74)(59-71)(60-61)(60-75)(61-74)(62-72)(63-73)(64-73)(65-72)(65-75)(66-77)(67-69)(67-78)(68-78)(69-71)(69-76)(70-79)(74-80)(75-80)(78-80)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| CH-1 | 29 | — | 10.1021/ic201801e | 2011 |
| SW480 | 49 | — | 10.1021/ic201801e | 2011 |
| A2780cisR | 66 | — | 10.1021/ic201801e | 2011 |
| A2780 | 85 | — | 10.1021/ic201801e | 2011 |
| A549 | 1.2e+02 | — | 10.1021/ic201801e | 2011 |
🧬 Cell Death Types (1)
Apoptosis
medium
«the appearance of a pronounced sub-G1/G0 fraction (excluded from analysis) and the tremendous decrease of the G2/M fraction (27 ± 6%) at this highest concentration suggest that apoptotic cell death is...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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