Info
| ID | 1802 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | 3c |
| SMILES | COCc1cccc2nc(-c3n[nH]c4ncc(Br)cc34)[nH]c12.O=Cc1ccc(OCC(=O)NCc2ccccc2)cc1.[Cl-] |
TUCAN
C31H27BrN6O4Ru/(1-28)(2-30)(3-31)(4-46)(5-54)(6-54)(7-29)(8-55)(9-52)(10-33)(11-37)(12-35)(13-53)(14-36)(15-32)(16-46)(17-34)(18-40)(19-39)(20-38)(21-45)(22-52)(23-52)(24-55)(25-62)(26-60)(27-61)(28-31)(28-42)(29-35)(29-41)(30-32)(30-42)(31-33)(32-33)(34-44)(34-58)(35-56)(36-37)(36-56)(37-41)(38-39)(38-40)(39-43)(40-48)(41-53)(42-46)(43-47)(43-55)(44-49)(44-51)(45-58)(45-59)(46-60)(47-48)(47-61)(48-63)(49-50)(49-64)(50-61)(50-63)(51-59)(51-62)(52-68)(53-66)(54-57)(54-67)(55-68)(56-67)(57-60)(57-65)(58-69)(62-64)(63-70)(64-70)(67-70)(68-70)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| CH-1 | 1.5e+02 | — | 10.1021/ic201801e | 2011 |
| SW480 | — | — | 10.1021/ic201801e | 2011 |
| A549 | — | — | 10.1021/ic201801e | 2011 |
| A2780 | — | — | 10.1021/ic201801e | 2011 |
| A2780cisR | — | — | 10.1021/ic201801e | 2011 |
🧬 Cell Death Types (1)
Apoptosis
medium
«the appearance of a pronounced sub-G1/G0 fraction (excluded from analysis) and the tremendous decrease of the G2/M fraction (27 ± 6%) at this highest concentration suggest that apoptotic cell death is...»