Info
| ID | 1801 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | 2c |
| SMILES | Brc1cnc2[nH]nc(-c3nc4ccccc4[nH]3)c2c1.O=Cc1ccc(OCC(=O)NCc2ccccc2)cc1.[Cl-] |
TUCAN
C29H23BrN6O3Ru/(1-25)(2-49)(3-29)(4-24)(5-28)(6-36)(7-42)(8-35)(9-33)(10-48)(11-27)(12-32)(13-34)(14-49)(15-26)(16-42)(17-31)(18-30)(19-41)(20-37)(21-54)(22-56)(23-55)(24-29)(24-38)(25-27)(25-39)(26-33)(26-38)(27-50)(28-29)(28-33)(30-31)(30-44)(31-35)(32-34)(32-50)(34-39)(35-37)(36-40)(36-52)(37-43)(38-42)(39-48)(40-45)(40-46)(41-52)(41-57)(42-54)(43-44)(43-53)(44-55)(45-47)(45-58)(46-56)(46-57)(47-53)(47-55)(48-59)(49-51)(49-61)(50-61)(51-54)(51-60)(52-62)(56-58)(57-63)(58-63)(61-63)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| CH-1 | 32 | — | 10.1021/ic201801e | 2011 |
| SW480 | — | — | 10.1021/ic201801e | 2011 |
| A549 | — | — | 10.1021/ic201801e | 2011 |
| A2780 | — | — | 10.1021/ic201801e | 2011 |
| A2780cisR | — | — | 10.1021/ic201801e | 2011 |
🧬 Cell Death Types (1)
Apoptosis
medium
«the appearance of a pronounced sub-G1/G0 fraction (excluded from analysis) and the tremendous decrease of the G2/M fraction (27 ± 6%) at this highest concentration suggest that apoptotic cell death is...»