Info
| ID | 1772 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 5 |
| SMILES | c1cnc2c(c1)c1nc3ccc4nccnc4c3nc1c1cccnc12.c1cnc2c(ccc3nccnc32)n1.c1cnc2c(ccc3nccnc32)n1 |
TUCAN
C40H22N14Ru/(1-23)(2-30)(3-37)(4-46)(5-27)(6-35)(7-36)(8-40)(9-38)(10-44)(11-25)(12-42)(13-32)(14-28)(15-45)(16-24)(17-31)(18-41)(19-26)(20-39)(21-43)(22-29)(23-24)(23-54)(24-53)(25-30)(25-35)(26-28)(26-57)(27-32)(27-41)(28-51)(29-31)(29-60)(30-34)(31-62)(32-33)(33-49)(33-56)(34-47)(34-58)(35-64)(36-38)(36-71)(37-40)(37-67)(38-63)(39-42)(39-68)(40-74)(41-72)(42-75)(43-45)(43-65)(44-46)(44-70)(45-73)(46-66)(47-49)(47-64)(48-52)(48-54)(48-71)(49-72)(50-57)(50-59)(50-69)(51-59)(51-66)(52-53)(52-67)(53-74)(54-63)(55-61)(55-62)(55-68)(56-58)(56-76)(57-76)(58-69)(59-70)(60-61)(60-65)(61-73)(62-75)(71-77)(72-77)(73-77)(74-77)(75-77)(76-77)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| Mutu-I | 40 | 18 | 10.1021/acs.jmedchem.5b00451 | 2015 |
| HeLa | 70 | 8.8 | 10.1021/acs.jmedchem.5b00451 | 2015 |
| CRL 5915 | — | 43 | 10.1021/acs.jmedchem.5b00451 | 2015 |
| ONE58 | — | 38 | 10.1021/acs.jmedchem.5b00451 | 2015 |
| DG-75 | — | 42 | 10.1021/acs.jmedchem.5b00451 | 2015 |
🧬 Cell Death Types (1)
Apoptosis
high
«upon visible light activation it induces caspase-dependent and reactive-oxygen-species-dependent apoptosis»