Info
| ID | 1771 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 4 |
| SMILES | c1cnc2c(c1)c1nc3ccc4nccnc4c3nc1c1cccnc12.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C44H26N10Ru/(1-28)(2-27)(3-57)(4-51)(5-52)(6-29)(7-32)(8-53)(9-44)(10-33)(11-56)(12-37)(13-34)(14-35)(15-42)(16-54)(17-38)(18-39)(19-40)(20-30)(21-55)(22-58)(23-43)(24-36)(25-31)(26-41)(27-32)(27-45)(28-30)(28-45)(29-33)(29-47)(30-47)(31-41)(31-48)(32-51)(33-52)(34-44)(34-46)(35-36)(35-65)(36-70)(37-39)(37-53)(38-40)(38-56)(39-48)(40-49)(41-49)(42-43)(42-50)(43-58)(44-57)(45-59)(46-64)(46-67)(47-60)(48-61)(49-66)(50-68)(50-69)(51-75)(52-76)(53-77)(54-55)(54-71)(55-74)(56-80)(57-73)(58-78)(59-60)(59-75)(60-76)(61-66)(61-77)(62-63)(62-65)(62-72)(63-70)(63-71)(64-68)(64-72)(65-79)(66-80)(67-69)(67-73)(68-79)(69-78)(70-74)(75-81)(76-81)(77-81)(78-81)(79-81)(80-81)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| ONE58 | 53 | 62 | 10.1021/acs.jmedchem.5b00451 | 2015 |
| CRL 5915 | 73 | 92 | 10.1021/acs.jmedchem.5b00451 | 2015 |
| HeLa | — | — | 10.1021/acs.jmedchem.5b00451 | 2015 |
| Mutu-I | — | — | 10.1021/acs.jmedchem.5b00451 | 2015 |
| DG-75 | — | 90 | 10.1021/acs.jmedchem.5b00451 | 2015 |
🧬 Cell Death Types (1)
Apoptosis
high
«upon visible light activation it induces caspase-dependent and reactive-oxygen-species-dependent apoptosis»