Info
| ID | 1676 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | RuY1 |
| SMILES | c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1.c1ccc2[n-]c(-c3ccc4ccc(-c5nc6ccccc6[nH]5)nc4n3)nc2c1 |
TUCAN
C42H29N10Ru/(1-36)(2-44)(3-49)(4-47)(5-35)(6-38)(7-45)(8-39)(9-55)(10-33)(11-34)(12-56)(13-57)(14-32)(15-37)(16-58)(17-30)(18-48)(19-40)(20-46)(21-42)(22-41)(23-43)(24-31)(25-51)(26-53)(27-50)(28-52)(29-75)(30-32)(30-66)(31-46)(31-54)(32-41)(33-34)(33-59)(34-49)(35-36)(35-55)(36-44)(37-38)(37-56)(38-45)(39-40)(39-51)(40-57)(41-48)(42-43)(42-54)(43-65)(44-60)(45-61)(46-64)(47-49)(47-63)(48-62)(50-53)(50-58)(51-67)(52-53)(52-68)(54-69)(55-77)(56-78)(57-80)(58-81)(59-63)(59-76)(60-68)(60-77)(61-67)(61-78)(62-66)(62-72)(63-75)(64-70)(64-74)(65-71)(65-73)(66-79)(67-80)(68-81)(69-73)(69-74)(70-75)(70-76)(71-72)(71-79)(76-82)(77-82)(78-82)(79-82)(80-82)(81-82)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 10 | — | 10.1021/acs.inorgchem.2c00714 | 2022 |
| A549 | 23 | — | 10.1021/acs.inorgchem.2c00714 | 2022 |
| A549cisR | 29 | — | 10.1021/acs.inorgchem.2c00714 | 2022 |
| HaCaT | 42 | — | 10.1021/acs.inorgchem.2c00714 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«According to the results, cell death was caused by apoptosis rather than necrosis, which proved that these Ru(II) polypyridyl complexes induce cell death through the apoptotic pathway.»