Info
| ID | 1675 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | RuY |
| SMILES | c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2nc3ccccc3[n-]2)nc1 |
TUCAN
C32H24N7Ru/(1-28)(2-44)(3-29)(4-31)(5-36)(6-27)(7-38)(8-34)(9-45)(10-32)(11-33)(12-37)(13-26)(14-41)(15-35)(16-42)(17-25)(18-48)(19-30)(20-39)(21-40)(22-46)(23-43)(24-47)(25-39)(25-48)(26-31)(26-49)(27-28)(27-32)(28-51)(29-34)(29-52)(30-36)(30-50)(31-36)(32-44)(33-34)(33-45)(35-38)(35-40)(37-39)(37-55)(38-53)(40-46)(41-42)(41-54)(42-43)(43-47)(44-58)(45-60)(46-61)(47-63)(48-57)(49-50)(49-59)(50-62)(51-52)(51-58)(52-60)(53-54)(53-61)(54-63)(55-56)(55-57)(56-59)(56-62)(58-64)(59-64)(60-64)(61-64)(62-64)(63-64)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 15 | — | 10.1021/acs.inorgchem.2c00714 | 2022 |
| A549 | 21 | — | 10.1021/acs.inorgchem.2c00714 | 2022 |
| A549cisR | 26 | — | 10.1021/acs.inorgchem.2c00714 | 2022 |
| HaCaT | 45 | — | 10.1021/acs.inorgchem.2c00714 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«According to the results, cell death was caused by apoptosis rather than necrosis, which proved that these Ru(II) polypyridyl complexes induce cell death through the apoptotic pathway.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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