Info
| ID | 1669 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2, "S": 2, "P": 1} |
| Abbreviation | Complex 8 |
| SMILES | Cc1ccc(C(C)C)cc1.N#C/C([S-])=C(/[S-])C#N.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C32N2PRuS2/(1-23)(2-25)(3-25)(4-5)(4-7)(5-6)(6-8)(7-28)(8-28)(9-11)(9-29)(10-14)(10-29)(11-16)(12-15)(12-30)(13-21)(13-30)(14-16)(15-19)(17-20)(17-24)(18-22)(18-24)(19-21)(20-23)(22-23)(24-25)(26-31)(26-33)(27-32)(27-34)(28-35)(29-35)(30-35)(31-32)(31-36)(32-37)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 0.96 | — | 10.1002/cbic.202200259 | 2022 |
| A2780cisR | 0.98 | — | 10.1002/cbic.202200259 | 2022 |
| PNT2 | 2.4 | — | 10.1002/cbic.202200259 | 2022 |
| NCI-H460 | 5.7 | — | 10.1002/cbic.202200259 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«Both complexes 6 and 8 induce apoptosis of A2780 cells and treatment with the complexes results in 99.6% and 95.4% of the cells in late apoptosis, respectively.»