Info
| ID | 1668 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | -2 |
| Donor atoms | {"N": 2, "S": 2, "O": 2, "P": 1} |
| Abbreviation | Complex 7 |
| SMILES | Cc1ccc(C(C)C)cc1.N#C/C([S-])=C(/[S-])C#N.O=S(=O)([O-])c1cccc(P(c2ccc(C(F)(F)F)cc2)c2cccc(S(=O)(=O)[O-])c2)c1 |
TUCAN
C33H26F3N2O6PRuS4/(1-27)(2-31)(3-30)(4-27)(5-34)(6-35)(7-37)(8-41)(9-38)(10-36)(11-39)(12-43)(13-33)(14-44)(15-42)(16-40)(17-32)(18-27)(19-28)(20-28)(21-28)(22-49)(23-29)(24-29)(25-29)(26-45)(27-47)(28-49)(29-49)(30-31)(30-47)(31-48)(32-45)(32-48)(33-37)(33-46)(34-35)(34-58)(35-38)(36-39)(36-40)(37-53)(38-54)(39-55)(40-59)(41-54)(41-58)(42-55)(42-59)(43-44)(43-53)(44-46)(45-47)(46-52)(48-49)(50-56)(50-60)(51-57)(51-61)(52-68)(52-69)(52-70)(53-71)(54-71)(55-71)(56-57)(56-72)(57-73)(58-75)(59-74)(62-74)(63-74)(64-74)(65-75)(66-75)(67-75)(71-76)(74-76)(75-76)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| PNT2 | 2.2 | — | 10.1002/cbic.202200259 | 2022 |
| A2780cisR | 2.3 | — | 10.1002/cbic.202200259 | 2022 |
| NCI-H460 | 2.3 | — | 10.1002/cbic.202200259 | 2022 |
| A2780 | 2.8 | — | 10.1002/cbic.202200259 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«Both complexes 6 and 8 induce apoptosis of A2780 cells and treatment with the complexes results in 99.6% and 95.4% of the cells in late apoptosis, respectively.»