Info
| ID | 1667 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | -3 |
| Donor atoms | {"N": 2, "S": 2, "O": 3, "P": 1} |
| Abbreviation | Complex 6 |
| SMILES | Cc1ccc(C(C)C)cc1.N#C/C([S-])=C(/[S-])C#N.O=S(=O)([O-])c1cccc(P(c2cccc(S(=O)(=O)[O-])c2)c2cccc(S(=O)(=O)[O-])c2)c1 |
TUCAN
C32H26N2O9PRuS5/(1-31)(2-48)(3-32)(4-27)(5-34)(6-35)(7-30)(8-37)(9-36)(10-39)(11-42)(12-43)(13-40)(14-44)(15-38)(16-41)(17-28)(18-27)(19-28)(20-28)(21-27)(22-29)(23-45)(24-29)(25-29)(26-33)(27-46)(28-48)(29-48)(30-34)(30-55)(31-32)(31-46)(32-47)(33-45)(33-47)(34-35)(35-51)(36-39)(36-41)(37-51)(37-55)(38-44)(38-57)(39-52)(40-44)(40-53)(41-58)(42-52)(42-58)(43-53)(43-57)(45-46)(47-48)(49-54)(49-59)(50-56)(50-60)(51-70)(52-70)(53-70)(54-56)(54-71)(55-73)(56-72)(57-74)(58-75)(61-73)(62-73)(63-73)(64-74)(65-74)(66-74)(67-75)(68-75)(69-75)(70-76)(73-76)(74-76)(75-76)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 0.6 | — | 10.1002/cbic.202200259 | 2022 |
| A2780cisR | 1.3 | — | 10.1002/cbic.202200259 | 2022 |
| PNT2 | 1.6 | — | 10.1002/cbic.202200259 | 2022 |
| NCI-H460 | 2 | — | 10.1002/cbic.202200259 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«Both complexes 6 and 8 induce apoptosis of A2780 cells and treatment with the complexes results in 99.6% and 95.4% of the cells in late apoptosis, respectively.»