Info
| ID | 1666 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 5, "P": 1, "S": 2} |
| Abbreviation | Complex 5 |
| SMILES | CC(=O)N1CN2CN(C(C)=O)CP(C2)C1.Cc1ccc(C(C)C)cc1.N#C/C([S-])=C(/[S-])C#N |
TUCAN
C23N5O2PRuS2/(1-10)(2-17)(3-18)(4-12)(5-12)(6-7)(6-10)(7-11)(8-9)(8-10)(9-11)(11-12)(13-22)(13-24)(14-23)(14-25)(15-26)(15-27)(16-27)(16-28)(17-26)(17-29)(18-28)(18-30)(19-26)(19-31)(20-27)(20-31)(21-28)(21-31)(22-23)(22-32)(23-33)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 14 | — | 10.1002/cbic.202200259 | 2022 |
| PNT2 | 33 | — | 10.1002/cbic.202200259 | 2022 |
| A2780cisR | 72 | — | 10.1002/cbic.202200259 | 2022 |
| NCI-H460 | — | — | 10.1002/cbic.202200259 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«Both complexes 6 and 8 induce apoptosis of A2780 cells and treatment with the complexes results in 99.6% and 95.4% of the cells in late apoptosis, respectively.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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