Info
| ID | 1665 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 5, "P": 1, "S": 2} |
| Abbreviation | Complex 4 |
| SMILES | C1N2CN3CN1CP(C2)C3.Cc1ccc(C(C)C)cc1.N#C/C([S-])=C(/[S-])C#N |
TUCAN
C20N5PRuS2/(1-10)(2-8)(3-10)(4-5)(4-9)(5-8)(6-7)(6-9)(7-8)(9-10)(11-19)(11-21)(12-20)(12-22)(13-23)(13-24)(14-23)(14-25)(15-24)(15-25)(16-23)(16-26)(17-24)(17-26)(18-25)(18-26)(19-20)(19-27)(20-28)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | — | — | 10.1002/cbic.202200259 | 2022 |
| A2780cisR | — | — | 10.1002/cbic.202200259 | 2022 |
| NCI-H460 | — | — | 10.1002/cbic.202200259 | 2022 |
| PNT2 | — | — | 10.1002/cbic.202200259 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«Both complexes 6 and 8 induce apoptosis of A2780 cells and treatment with the complexes results in 99.6% and 95.4% of the cells in late apoptosis, respectively.»