Info
| ID | 164 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ru6 |
| SMILES | Cc1c(C)c(C)c(Cn2[c-][n+](C3=NC4C=CC=CC4S3)cc2)c(C)c1C.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C32H39N3RuS/(1-53)(2-70)(3-65)(4-45)(5-64)(6-40)(7-40)(8-40)(9-41)(10-50)(11-41)(12-42)(13-43)(14-41)(15-48)(16-51)(17-49)(18-66)(19-52)(20-67)(21-67)(22-68)(23-43)(24-43)(25-55)(26-42)(27-42)(28-54)(29-44)(30-45)(31-45)(32-47)(33-47)(34-44)(35-46)(36-44)(37-47)(38-46)(39-46)(40-64)(41-64)(42-56)(43-57)(44-61)(45-60)(46-62)(47-63)(48-50)(48-60)(49-51)(49-60)(50-59)(51-59)(52-53)(52-70)(53-54)(54-55)(55-68)(56-57)(56-58)(57-62)(58-63)(58-67)(59-64)(61-62)(61-63)(65-66)(65-73)(66-72)(67-73)(68-70)(68-74)(69-72)(69-73)(70-75)(71-72)(71-74)(71-75)(74-76)(75-76)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 2 | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| HT-29 | 3.2 | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| LoVo | 12 | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| HCT-116 | 13 | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| A549 | 20 | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| HeLa | 23 | — | 10.1016/j.ejmech.2020.112605 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Ru4 and Ru6 complexes induced apoptosis in a caspase-dependent manner, primarily through intracellular reactive oxygen species (ROS) overproduction and cell cycle arrest at G1 phase.»