Info
| ID | 1623 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 1} |
| Abbreviation | 2c |
| SMILES | Cc1ccc(C(C)C)cc1.O=C(CCc1cccnc1)OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.[Cl-].[Cl-] |
TUCAN
C30Cl2F21NO2Ru/(1-14)(2-13)(3-13)(4-7)(4-15)(5-6)(5-16)(6-20)(7-14)(8-9)(8-14)(9-15)(10-11)(10-16)(11-17)(12-19)(12-25)(13-15)(16-18)(17-31)(18-31)(19-33)(20-32)(20-33)(21-22)(21-28)(21-34)(21-35)(22-23)(22-36)(22-37)(23-24)(23-38)(23-39)(24-26)(24-40)(24-41)(25-28)(25-42)(25-45)(26-27)(26-43)(26-44)(27-29)(27-46)(27-47)(28-48)(28-51)(29-30)(29-49)(29-50)(30-52)(30-53)(30-54)
Measurements (10)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HUVEC | 43 | — | 10.1021/acs.molpharmaceut.5b00... | 2015 |
| ECRF24 | 56 | — | 10.1021/acs.molpharmaceut.5b00... | 2015 |
| A2780 | — | — | 10.1039/C3SC53185F | 2014 |
| A2780cisR | — | — | 10.1039/C3SC53185F | 2014 |
| MCF-7 | — | — | 10.1039/C3SC53185F | 2014 |
| MDA-MB-231 | — | — | 10.1039/C3SC53185F | 2014 |
| A549 | — | — | 10.1039/C3SC53185F | 2014 |
| HEK293 | — | — | 10.1039/C3SC53185F | 2014 |
| SW480 | — | — | 10.1021/acs.molpharmaceut.5b00... | 2015 |
| LS 174T | — | — | 10.1021/acs.molpharmaceut.5b00... | 2015 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complexes 1 and 2 induce apoptosis in ECRF24 cells in a dose-dependent manner (Table 2), determined by FACS analysis of subdiploid cells after exposure to a 50 μM dose. As reported previously, 1 induc...»
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Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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