Info
| ID | 162 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ru4 |
| SMILES | CCCCCCCCn1[c-][n+](C2=NC3C=CC=CC3S2)cc1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C28H39N3RuS/(1-64)(2-60)(3-40)(4-40)(5-40)(6-41)(7-44)(8-41)(9-49)(10-66)(11-41)(12-45)(13-47)(14-46)(15-42)(16-42)(17-53)(18-42)(19-52)(20-53)(21-56)(22-52)(23-55)(24-56)(25-57)(26-57)(27-63)(28-63)(29-54)(30-54)(31-51)(32-43)(33-61)(34-43)(35-43)(36-50)(37-48)(38-62)(39-55)(40-60)(41-60)(42-53)(43-59)(44-45)(44-58)(45-59)(46-47)(46-59)(47-58)(48-50)(48-51)(49-50)(49-66)(51-64)(52-53)(52-56)(54-55)(54-57)(55-56)(57-63)(58-60)(61-62)(61-69)(62-68)(63-69)(64-66)(64-70)(65-68)(65-69)(66-71)(67-68)(67-70)(67-71)(70-72)(71-72)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 2.7 | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| HT-29 | 5.2 | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| LoVo | 19 | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| A549 | 25 | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| HCT-116 | 26 | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| HeLa | 39 | — | 10.1016/j.ejmech.2020.112605 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Ru4 and Ru6 complexes induced apoptosis in a caspase-dependent manner, primarily through intracellular reactive oxygen species (ROS) overproduction and cell cycle arrest at G1 phase.»