Info
| ID | 1614 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 1} |
| Abbreviation | 1 |
| SMILES | Cc1ccc(C(C)C)cc1.O=C(CCc1cccnc1)OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.[Cl-].[Cl-] |
TUCAN
C28Cl2F17NO2Ru/(1-14)(2-13)(3-13)(4-7)(4-15)(5-6)(5-16)(6-20)(7-14)(8-9)(8-14)(9-15)(10-11)(10-16)(11-17)(12-19)(12-24)(13-15)(16-18)(17-29)(18-29)(19-31)(20-30)(20-31)(21-22)(21-27)(21-34)(21-35)(22-23)(22-36)(22-37)(23-25)(23-38)(23-39)(24-27)(24-41)(24-43)(25-26)(25-40)(25-42)(26-28)(26-44)(26-45)(27-32)(27-33)(28-46)(28-47)(28-48)
Measurements (18)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780cisR | 25 | — | 10.1039/C3SC53185F | 2014 |
| A2780cisR | 25 | — | 10.1021/jm5002748 | 2014 |
| MDA-MB-231 | 36 | — | 10.1039/C3SC53185F | 2014 |
| MDA-MB-231 | 36 | — | 10.1021/jm5002748 | 2014 |
| MCF-7 | 38 | — | 10.1039/C3SC53185F | 2014 |
| MCF-7 | 38 | — | 10.1021/jm5002748 | 2014 |
| SW480 | 41 | — | 10.1021/acs.molpharmaceut.5b00... | 2015 |
| A549 | 43 | — | 10.1039/C3SC53185F | 2014 |
| A549 | 43 | — | 10.1021/jm5002748 | 2014 |
| A2780 | 44 | — | 10.1039/C3SC53185F | 2014 |
| A2780 | 44 | — | 10.1021/jm5002748 | 2014 |
| ECRF24 | 53 | — | 10.1021/acs.molpharmaceut.5b00... | 2015 |
| ECRF24 | 56 | — | 10.1021/jm501655t | 2015 |
| HUVEC | — | — | 10.1021/jm501655t | 2015 |
| HEK293 | — | — | 10.1039/C3SC53185F | 2014 |
| LS 174T | — | — | 10.1021/acs.molpharmaceut.5b00... | 2015 |
| HUVEC | — | — | 10.1021/acs.molpharmaceut.5b00... | 2015 |
| HEK293 | — | — | 10.1021/jm5002748 | 2014 |
🧬 Cell Death Types (1)
Apoptosis
high
«For 1, only a moderate induction of apoptosis was observed in A2780 cells»