Info
| ID | 161 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ru3 |
| SMILES | CCCCn1[c-][n+](C2=NC3C=CC=CC3S2)cc1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C24H31N3RuS/(1-39)(2-48)(3-32)(4-32)(5-32)(6-34)(7-36)(8-34)(9-34)(10-37)(11-40)(12-41)(13-45)(14-35)(15-44)(16-45)(17-43)(18-52)(19-42)(20-35)(21-35)(22-38)(23-51)(24-51)(25-54)(26-33)(27-33)(28-33)(29-49)(30-50)(31-44)(32-48)(33-46)(34-48)(35-45)(36-37)(36-47)(37-46)(38-39)(38-42)(39-54)(40-41)(40-47)(41-46)(42-43)(43-52)(44-45)(44-51)(47-48)(49-50)(49-56)(50-57)(51-56)(52-54)(52-58)(53-56)(53-57)(54-59)(55-57)(55-58)(55-59)(58-60)(59-60)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | — | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| HT-29 | — | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| HCT-116 | — | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| LoVo | — | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| HeLa | — | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| A2780 | — | — | 10.1016/j.ejmech.2020.112605 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Ru4 and Ru6 complexes induced apoptosis in a caspase-dependent manner, primarily through intracellular reactive oxygen species (ROS) overproduction and cell cycle arrest at G1 phase.»