Info
| ID | 160 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ru2 |
| SMILES | CC(C)n1[c-][n+](C2=NC3C=CC=CC3S2)cc1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C23H29N3RuS/(1-45)(2-31)(3-31)(4-31)(5-32)(6-35)(7-32)(8-32)(9-36)(10-37)(11-38)(12-41)(13-40)(14-33)(15-33)(16-39)(17-42)(18-49)(19-51)(20-30)(21-30)(22-30)(23-47)(24-46)(25-33)(26-48)(27-34)(28-34)(29-34)(30-43)(31-45)(32-45)(33-48)(34-48)(35-36)(35-44)(36-43)(37-38)(37-44)(38-43)(39-40)(39-51)(40-41)(41-42)(42-49)(44-45)(46-47)(46-53)(47-54)(48-54)(49-51)(49-55)(50-53)(50-54)(51-56)(52-53)(52-55)(52-56)(55-57)(56-57)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 84 | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| A549 | — | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| HT-29 | — | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| HCT-116 | — | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| LoVo | — | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| HeLa | — | — | 10.1016/j.ejmech.2020.112605 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Ru4 and Ru6 complexes induced apoptosis in a caspase-dependent manner, primarily through intracellular reactive oxygen species (ROS) overproduction and cell cycle arrest at G1 phase.»