Info
| ID | 159 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ru1 |
| SMILES | Cc1ccc(C(C)C)cc1.Cn1[c-][n+](C2=NC3C=CC=CC3S2)cc1.[Cl-] |
TUCAN
C21H25N3RuS/(1-26)(2-33)(3-27)(4-32)(5-26)(6-40)(7-35)(8-29)(9-45)(10-30)(11-41)(12-43)(13-31)(14-42)(15-40)(16-40)(17-27)(18-27)(19-28)(20-36)(21-39)(22-26)(23-28)(24-34)(25-28)(26-37)(27-39)(28-39)(29-31)(29-43)(30-31)(30-35)(32-33)(32-37)(33-38)(34-36)(34-38)(35-45)(36-37)(38-39)(40-47)(41-42)(41-48)(42-47)(43-45)(43-49)(44-47)(44-48)(45-50)(46-48)(46-49)(46-50)(49-51)(50-51)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | — | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| HT-29 | — | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| HCT-116 | — | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| LoVo | — | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| HeLa | — | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| A2780 | — | — | 10.1016/j.ejmech.2020.112605 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Ru4 and Ru6 complexes induced apoptosis in a caspase-dependent manner, primarily through intracellular reactive oxygen species (ROS) overproduction and cell cycle arrest at G1 phase.»