Info
| ID | 1584 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | 4 |
| SMILES | CC(C)c1cc(C(C)C)cc(C(C)C)c1.COc1ccc(/N=C/c2ccc3ccccc3n2)cc1.[Cl-] |
TUCAN
C32H38N2ORu/(1-45)(2-69)(3-46)(4-69)(5-51)(6-39)(7-39)(8-39)(9-40)(10-62)(11-40)(12-40)(13-63)(14-52)(15-54)(16-47)(17-56)(18-48)(19-55)(20-65)(21-57)(22-69)(23-50)(24-49)(25-41)(26-41)(27-41)(28-53)(29-42)(30-42)(31-42)(32-43)(33-43)(34-64)(35-43)(36-44)(37-44)(38-44)(39-62)(40-62)(41-63)(42-63)(43-64)(44-64)(45-46)(45-67)(46-70)(47-49)(47-70)(48-50)(48-66)(49-67)(50-58)(51-59)(51-60)(52-59)(52-61)(53-60)(53-61)(54-56)(54-57)(55-56)(55-68)(57-58)(58-68)(59-62)(60-63)(61-64)(65-66)(65-72)(66-71)(67-72)(68-71)(69-73)(70-73)(71-74)(72-74)
Measurements (16)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 0.53 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| HCT-116 p53-/- | 0.73 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| AGS | 0.74 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| A2780cisR | 0.87 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| HT-29 | 0.91 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| AGS | 1 | — | 10.1039/C6SC00268D | 2016 |
| HCT-116 | 1.1 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| HCT-116 | 1.2 | — | 10.1039/C6SC00268D | 2016 |
| KATO III | 1.2 | — | 10.1039/C6SC00268D | 2016 |
| HT-29 | 1.9 | — | 10.1039/C6SC00268D | 2016 |
| A2780 | 2.8 | — | 10.1021/jm500455p | 2014 |
| MCF-7 | 2.9 | — | 10.1021/jm500455p | 2014 |
| TC7 | 3 | — | 10.1021/acs.molpharmaceut.8b00... | 2018 |
| A2780cisR | 3.2 | — | 10.1021/jm500455p | 2014 |
| SW480 | 4.1 | — | 10.1039/C6SC00268D | 2016 |
| TC7 | 8.7 | — | 10.1039/C6SC00268D | 2016 |
🧬 Cell Death Types (1)
Apoptosis
low
«The article does not explicitly state that the complexes induce apoptosis; it focuses on ER stress and non-apoptotic cell death. However, the introduction mentions that ER stress can lead to apoptosis...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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