Info
| ID | 158 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | RDC34 |
| SMILES | [c-]1ccccc1-c1ccccn1.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C35H24N5Ru/(1-27)(2-28)(3-43)(4-32)(5-54)(6-50)(7-26)(8-30)(9-29)(10-51)(11-35)(12-52)(13-39)(14-31)(15-40)(16-38)(17-37)(18-42)(19-53)(20-44)(21-41)(22-36)(23-33)(24-34)(25-31)(25-49)(26-35)(26-45)(27-28)(27-45)(28-46)(29-38)(29-46)(30-36)(30-47)(31-32)(32-34)(33-34)(33-49)(35-50)(36-48)(37-42)(37-47)(38-51)(39-40)(39-43)(40-59)(41-44)(41-48)(42-52)(43-54)(44-53)(45-55)(46-56)(47-57)(48-58)(49-59)(50-60)(51-61)(52-62)(53-64)(54-63)(55-56)(55-60)(56-61)(57-58)(57-62)(58-64)(59-63)(60-65)(61-65)(62-65)(63-65)(64-65)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 0.1 | — | 10.1039/c1dt10322a | 2011 |
| HCT-116 | 0.1 | — | 10.1039/c1dt10322a | 2011 |
| HCT-116 | 0.15 | — | 10.1039/C9QI01148J | 2020 |
| A172 | 0.25 | — | 10.1021/ic500250e | 2014 |
| HCT-116 | 0.25 | — | 10.1016/j.bcp.2012.08.022 | 2012 |
🧬 Cell Death Types (1)
Apoptosis
high
«RDC34 was as efficient as RDC11 to induce CHOP, but was more potent to induce p53 protein levels... RDC34 increased the expression of pro-apoptotic p53 target genes... RDC34 was more potent in inducin...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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