Info
| ID | 1563 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 3} |
| Abbreviation | 2 |
| SMILES | CN(C)c1ccc(/N=C/c2ccccn2)cc1.Cc1ccc(C(C)C)cc1.[I-] |
TUCAN
C24H29N3Ru/(1-46)(2-30)(3-34)(4-30)(5-30)(6-38)(7-32)(8-32)(9-31)(10-32)(11-33)(12-43)(13-50)(14-36)(15-35)(16-47)(17-47)(18-47)(19-42)(20-48)(21-39)(22-48)(23-49)(24-31)(25-31)(26-37)(27-41)(28-40)(29-48)(30-46)(31-45)(32-46)(33-34)(33-45)(34-44)(35-36)(35-53)(36-52)(37-38)(37-45)(38-44)(39-42)(39-43)(40-41)(40-52)(41-53)(42-49)(43-51)(44-46)(47-54)(48-54)(49-55)(50-51)(50-56)(51-55)(52-56)(53-54)(55-57)(56-57)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 3 | — | 10.1021/jm3017442 | 2013 |
| A2780 | 3 | — | 10.1039/c2mt20189e | 2012 |
| MCF-7 | 4.4 | — | 10.1021/jm3017442 | 2013 |
| HCT-116 | 8.6 | — | 10.1021/jm3017442 | 2013 |
| A549 | 15 | — | 10.1021/jm3017442 | 2013 |
🧬 Cell Death Types (1)
Apoptosis
high
«All complexes activate caspase 3. Remarkably, the level of activation of caspase 3 by the chlorido complexes 1, 3, and 5 is 2-fold higher than by the iodido complexes 2, 4, and 6 (Supporting Informati...»
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