Info
| ID | 156 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | Δ-Ru1 |
| SMILES | Oc1ccccc1-c1nc2c3cccnc3c3ncccc3c2[nH]1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C39H28N8ORu/(1-52)(2-36)(3-37)(4-35)(5-53)(6-30)(7-29)(8-39)(9-38)(10-31)(11-32)(12-43)(13-48)(14-44)(15-55)(16-56)(17-54)(18-41)(19-33)(20-57)(21-42)(22-47)(23-34)(24-40)(25-46)(26-45)(27-69)(28-76)(29-30)(29-52)(30-35)(31-33)(31-53)(32-34)(32-54)(33-39)(34-41)(35-59)(36-38)(36-55)(37-43)(37-49)(38-51)(39-60)(40-45)(40-46)(41-61)(42-47)(42-56)(43-44)(44-48)(45-57)(46-62)(47-50)(48-67)(49-66)(49-67)(50-58)(50-64)(51-63)(51-65)(52-70)(53-71)(54-74)(55-68)(56-73)(57-75)(58-65)(58-72)(59-60)(59-70)(60-71)(61-62)(61-74)(62-75)(63-64)(63-68)(64-73)(65-69)(66-69)(66-72)(67-76)(70-77)(71-77)(72-77)(73-77)(74-77)(75-77)(76-77)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| B16-F10 | 3.9 | — | 10.3389/fonc.2020.00141 | 2020 |
| NCI-H1299 | 11 | — | 10.3389/fonc.2020.00141 | 2020 |
| MCF-7 | 24 | — | 10.3389/fonc.2020.00141 | 2020 |
| SW1116 | 40 | — | 10.3389/fonc.2020.00141 | 2020 |
| HepG2 | 46 | — | 10.3389/fonc.2020.00141 | 2020 |
| MDA-MB-231 | 88 | — | 10.3389/fonc.2020.00141 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«The results showed that the drug treatment resulted in significant apoptosis compared with the control group (Figure 4A). In addition, the early-phase apoptosis induced by the Δ-Ru1/Dox combination wa...»